UID 22RV1 23132-87 5637 639-V 647-V 769-P 786-0 8505C A172 A204 A2058 A2780 A375 A427 A431 A549 A673 ABC-1 ACHN AGS AN3-CA AsPC-1 BCPAP BEN BFTC-905 BFTC-909 BHT-101 BHY BT-20 BT-549 BxPC-3 C-33-A C-4-II C32 C3A CAKI-1 CAL-120 CAL-12T CAL-148 CAL-27 CAL-33 CAL-39 CAL-51 CAL-54 CAL-62 CAL-72 CAL-85-1 CAMA-1 CAPAN-1 CCF-STTG1 CFPAC-1 CHL-1 CHP-212 COLO-205 COLO-678 COLO-679 COLO-680N COLO-741 COLO-792 COLO-824 COR-L105 COR-L23 Ca-Ski Ca9-22 CaR-1 Calu-1 Calu-3 Caov-3 ChaGo-K-1 DBTRG-05MG DK-MG DMS-273 DMS-53 DOK DU-145 DV-90 Daoy Detroit562 DoTc2-4510 EFM-19 EFO-21 EFO-27 EGI-1 EPLC-272H ESS-1 EVSA-T FTC-133 FaDu G-361 G-401 GAMG GCT GMS-10 GP5d H-EMC-SS H4 HCC1143 HCC1395 HCC1419 HCC1806 HCC1937 HCC1954 HCC38 HCC70 HCT-116 HCT-15 HEC-1 HGC-27 HLE HMV-II HN HO-1-N-1 HOP-92 HOS HPAF-II HSC-2 HSC-3 HSC-4 HT-1080 HT-1197 HT-1376 HT-29 HT-3 HT55 HTC-C3 HUH-6-clone5 Hs-578-T HuCCT1 HuH-28 HuH-7 HuO-3N1 HuO9 HuP-T3 HuP-T4 IGR-1 IGROV-1 IPC-298 J82 JAR KATOIII KOSC-2 KP-4 KU-19-19 KYSE-140 KYSE-150 KYSE-180 KYSE-270 KYSE-410 KYSE-450 KYSE-510 KYSE-520 KYSE-70 LCLC-103H LCLC-97TM1 LK-2 LN-405 LS-174T LU-135 LU-99A LoVo M059J M14 MC-IXC MCF7 MDA-MB-157 MDA-MB-175-VII MDA-MB-231 MDA-MB-361 MDA-MB-415 MDA-MB-453 MDA-MB-468 ME-180 MEL-HO MEL-JUSO MES-SA MFE-280 MFE-296 MFM-223 MG-63 MHH-ES-1 MIA-PaCa-2 MKN1 MKN28 MKN45 MKN7 MOG-G-CCM MOG-G-UVW MSTO-211H Mewo NB69 NCCIT NCI-ADR-RES NCI-H1048 NCI-H1299 NCI-H1437 NCI-H1563 NCI-H1573 NCI-H1650 NCI-H1651 NCI-H1666 NCI-H1693 NCI-H1703 NCI-H1755 NCI-H1792 NCI-H1793 NCI-H1975 NCI-H1993 NCI-H2009 NCI-H2029 NCI-H2030 NCI-H2052 NCI-H2087 NCI-H2170 NCI-H2196 NCI-H2228 NCI-H23 NCI-H2342 NCI-H2347 NCI-H2405 NCI-H2452 NCI-H28 NCI-H292 NCI-H358 NCI-H441 NCI-H460 NCI-H520 NCI-H522 NCI-H596 NCI-H630 NCI-H650 NCI-H661 NCI-H727 NCI-H810 NCI-H838 NCI-N87 NCI-SNU-1 NCI-SNU-16 NCI-SNU-5 NH-6 NUGC-3 NY OAW-28 OAW-42 OE19 OE33 OVCAR-3 OVCAR-5 OVCAR-8 PA-1 PANC-03-27 PANC-08-13 PANC-10-05 PC-14 PC-3 PFSK-1 PLC-PRF-5 RCM-1 RD RERF-LC-MS RMG-I RO82-W-1 RPMI-2650 RPMI-7951 RT-112 RVH-421 S-117 SAS SBC-5 SCC-4 SCC-9 SCCH-26 SCH SCLC-21H SF295 SHP-77 SJRH30 SK-CO-1 SK-HEP-1 SK-LU-1 SK-MEL-2 SK-MEL-28 SK-MEL-3 SK-MEL-30 SK-MES-1 SK-N-AS SK-N-DZ SK-NEP-1 SK-OV-3 SKG-IIIa SN12C SNG-M SNU-387 SNU-423 SNU-449 SNU-475 SW1088 SW1116 SW13 SW1417 SW1463 SW1573 SW1710 SW1783 SW1990 SW48 SW620 SW626 SW780 SW837 SW900 SW948 Saos-2 SiHa T-24 T47D T84 T98G TCCSUP TCO-1 TGW TYK-nu U-118-MG U-2-OS U031 U251 UACC-62 UACC-812 UM-UC-3 UMC-11 VM-CUB-1 VMRC-MELG VMRC-RCZ WM-115 YAPC YKG-1 ZR-75-30 Paclitaxel_Bayesian_5pctCI_low 0.003 0.018 0.004 0.107 0.006 0.065 0.028 0.027 0.005 0.006 0.038 0.074 0.073 0.091 0.017 0.008 0.002 0.009 0.117 0.003 0.017 0.110 0.006 0.072 0.003 0.008 0.098 0.009 0.009 0.023 0.038 0.005 0.031 0.073 0.053 0.171 0.020 0.011 0.148 0.002 0.005 0.00001 0.076 0.073 0.027 0.009 0.009 0.013 0.042 0.049 0.015 0.002 0.026 0.015 0.209 0.108 0.021 0.038 0.061 0.044 0.004 0.006 0.016 0.002 0.030 0.014 0.049 0.002 0.005 0.012 0.011 0.004 0.113 0.003 0.003 0.021 0.006 0.001 0.012 0.071 0.160 0.022 0.007 0.037 0.005 0.008 0.017 0.005 0.017 0.106 0.005 0.003 0.075 0.029 0.100 0.030 0.003 0.042 0.045 0.013 0.026 0.040 0.006 0.014 0.021 0.018 0.006 0.004 0.047 0.085 0.007 0.003 0.193 0.002 0.035 0.003 0.002 0.004 0.002 0.018 0.002 0.050 0.069 0.047 0.061 0.081 0.025 0.002 0.030 0.023 0.000 0.009 0.005 0.007 0.005 0.156 0.135 0.080 0.002 0.004 0.006 0.005 0.017 0.042 0.006 0.003 0.005 0.004 0.002 0.002 0.004 0.033 0.003 0.001 0.008 0.038 0.792 0.014 0.006 0.038 0.002 0.006 0.006 0.017 0.131 0.197 0.007 0.188 0.022 0.043 0.015 0.022 0.084 0.073 0.004 0.102 0.001 0.014 0.006 0.003 0.073 0.004 0.068 0.006 0.242 0.003 0.010 0.172 0.006 0.009 0.003 0.267 0.006 0.007 0.001 0.181 0.007 0.016 0.005 0.014 0.027 0.003 0.023 0.013 0.011 0.009 0.002 0.013 0.720 0.030 0.005 0.140 0.002 0.232 0.019 0.025 0.422 0.004 0.023 0.007 0.011 0.002 0.007 0.042 0.008 0.064 0.011 0.017 0.630 0.002 0.004 0.107 0.025 0.020 0.012 0.025 0.005 0.006 0.052 0.002 0.003 0.028 0.133 0.006 0.017 0.008 0.024 0.036 0.002 0.008 0.061 0.008 0.003 0.005 0.002 0.069 0.020 0.003 0.012 0.022 0.090 0.017 0.025 0.005 0.058 0.033 0.077 0.010 0.002 0.003 0.009 0.053 0.008 0.124 0.157 0.002 0.012 0.028 0.015 0.102 0.015 0.349 0.277 0.034 0.005 0.016 0.009 0.007 0.402 0.001 0.002 0.015 0.003 0.166 0.005 0.030 0.344 0.058 0.300 0.270 0.072 0.012 0.025 0.040 0.003 0.136 0.001 0.012 0.445 0.004 0.248 0.010 0.038 0.088 0.017 0.107 0.005 0.042 0.014 0.089 0.022 0.014 0.023 0.129 0.002 0.015 0.150 0.035 0.012 0.004 0.024 0.045 0.007 0.053 0.012 0.129 Paclitaxel_11_IC50_uM 0.007 0.047 0.010 0.206 0.011 0.104 0.075 0.047 0.010 0.013 0.054 0.112 0.133 0.162 0.034 0.028 0.003 0.012 0.225 0.008 0.048 1.654 0.010 0.135 0.004 0.015 0.751 0.020 0.012 0.045 0.149 0.007 0.047 0.126 0.099 0.496 0.041 0.024 2.268 0.003 0.007 0.0001 0.139 0.334 0.079 0.013 0.050 0.018 0.185 0.205 0.055 0.003 0.041 0.025 0.991 0.320 0.039 0.058 0.097 0.471 0.005 0.014 0.035 0.003 0.061 0.064 0.147 0.004 0.010 0.023 0.018 0.008 0.185 0.005 0.005 0.034 0.011 0.002 0.017 0.169 0.587 0.040 0.012 0.088 0.007 0.017 0.032 0.007 0.027 0.319 0.009 0.004 0.186 0.117 0.328 0.041 0.005 0.066 0.141 0.018 0.090 0.061 0.012 0.025 0.041 0.039 0.009 0.006 0.064 0.295 0.014 0.004 0.733 0.004 0.099 0.004 0.003 0.008 0.003 0.066 0.003 0.078 0.154 0.115 0.206 0.150 0.062 0.005 0.052 0.077 0.004 0.021 0.010 0.014 0.008 0.433 0.796 0.154 0.002 0.008 0.010 0.012 0.038 0.071 0.008 0.004 0.009 0.006 0.004 0.002 0.008 0.087 0.003 0.002 0.026 0.137 35.609 0.023 0.009 0.059 0.006 0.010 0.010 0.041 0.556 1.088 0.014 4.493 0.050 0.065 0.027 0.036 0.189 0.125 0.006 0.236 0.003 0.025 0.013 0.005 0.299 0.016 0.222 0.018 3.685 0.004 0.014 0.892 0.010 0.016 0.006 3.608 0.009 0.014 0.003 0.722 0.011 0.027 0.011 0.019 0.062 0.004 0.041 0.024 0.022 0.015 0.009 0.019 19.860 0.054 0.024 0.333 0.003 5.574 0.057 0.032 14.732 0.010 0.073 0.009 0.016 0.004 0.012 0.271 0.025 0.149 0.041 0.036 19.463 0.007 0.008 0.697 0.058 0.032 0.025 0.111 0.008 0.039 0.157 0.003 0.006 0.069 0.297 0.013 0.028 0.015 0.057 0.056 0.003 0.055 0.157 0.013 0.006 0.006 0.004 0.228 0.141 0.005 0.016 0.036 0.638 0.035 0.036 0.009 0.112 0.267 0.164 0.014 0.004 0.005 0.025 0.089 0.016 0.297 0.383 0.004 0.024 0.091 0.033 0.210 0.035 7.660 4.072 0.057 0.010 0.028 0.021 0.016 10.240 0.002 0.004 0.022 0.004 1.111 0.008 0.050 8.267 0.099 6.765 3.523 0.147 0.018 0.036 0.078 0.005 0.494 0.002 0.022 9.519 0.008 4.366 0.014 0.066 0.134 0.044 0.259 0.007 0.480 0.032 0.163 0.048 0.025 0.035 0.235 0.004 0.026 1.680 0.068 0.029 0.005 0.044 0.191 0.020 0.552 0.021 0.535 Paclitaxel_Bayesian_5pctCI_high 0.015 0.163 0.034 0.742 0.020 0.205 0.310 0.089 0.021 0.034 0.073 0.198 0.395 0.379 0.072 0.137 0.004 0.019 0.739 0.018 0.191 893.369 0.018 0.322 0.006 0.030 115.735 0.046 0.016 0.101 1.635 0.010 0.074 0.293 0.234 4.976 0.089 0.057 2805.396 0.004 0.009 0.0003 0.379 7.335 0.393 0.018 0.463 0.026 2.941 2.881 0.379 0.004 0.068 0.044 26.967 5.442 0.078 0.083 0.175 102.463 0.007 0.037 0.090 0.005 0.145 0.856 0.894 0.006 0.022 0.045 0.029 0.016 0.438 0.007 0.008 0.053 0.019 0.004 0.027 0.782 9.952 0.072 0.021 0.326 0.011 0.036 0.062 0.009 0.041 3.117 0.014 0.006 0.894 1.069 3.316 0.055 0.008 0.101 1.144 0.027 0.498 0.088 0.022 0.045 0.087 0.081 0.013 0.008 0.082 3.141 0.029 0.005 13.609 0.008 0.410 0.006 0.005 0.016 0.004 0.455 0.005 0.129 0.444 0.494 2.377 0.432 0.183 0.009 0.090 0.410 0.102 0.048 0.021 0.027 0.013 3.849 54.861 0.458 0.003 0.014 0.014 0.028 0.091 0.136 0.013 0.007 0.014 0.008 0.006 0.004 0.014 0.332 0.005 0.004 0.126 1.203 356931.798 0.036 0.013 0.091 0.013 0.016 0.017 0.121 12.060 87.156 0.027 22196.724 0.134 0.101 0.050 0.059 0.926 0.269 0.008 1.583 0.006 0.044 0.026 0.008 5.745 0.121 1.949 0.061 903.251 0.006 0.021 47.309 0.015 0.027 0.011 1329.556 0.015 0.028 0.006 17.341 0.017 0.047 0.023 0.025 0.165 0.006 0.080 0.045 0.046 0.027 0.031 0.029 7023.381 0.105 0.196 1.448 0.004 31856.604 0.292 0.042 307490.663 0.023 0.359 0.013 0.024 0.006 0.020 18.754 0.106 0.526 0.270 0.095 13014.248 0.020 0.016 41.314 0.176 0.052 0.055 1.308 0.012 0.652 0.944 0.005 0.010 0.225 1.324 0.030 0.049 0.026 0.168 0.083 0.005 1.289 0.868 0.025 0.009 0.009 0.005 2.463 4.666 0.007 0.023 0.057 128.586 0.083 0.049 0.020 0.314 16.494 0.528 0.020 0.007 0.008 0.101 0.176 0.031 2.878 2.629 0.008 0.049 0.535 0.085 0.905 0.093 3234.081 2086.827 0.094 0.017 0.046 0.051 0.037 5665.214 0.003 0.006 0.033 0.007 161.080 0.015 0.090 4661.069 0.209 2565.991 956.901 0.441 0.027 0.053 0.185 0.008 15.632 0.005 0.040 3465.804 0.018 2679.271 0.019 0.128 0.247 0.145 1.570 0.011 69.623 0.066 0.538 0.111 0.047 0.052 0.726 0.006 0.046 399.654 0.150 0.076 0.007 0.080 2.337 0.069 93.813 0.039 19.175 HKI-272_Bayesian_5pctCI_low 0.620 2.167 0.156 5.545 0.373 0.830 0.781 2.644 1.262 0.334 3.857 6.953 2.446 4.837 1.946 0.352 0.183 3.552 0.826 0.245 0.701 1.285 0.896 8.495 1.188 0.990 4.198 0.039 0.482 1.842 1.073 0.130 0.135 7.570 0.689 2.845 0.987 0.122 4.117 0.054 0.210 0.000 2.062 1.289 6.661 0.747 0.311 1.936 3.623 14.090 0.111 0.029 0.566 2.978 3.341 4.886 0.271 0.983 1.620 3.932 2.182 0.196 0.342 0.118 1.869 0.688 0.000 0.789 0.114 0.227 0.678 2.356 13.711 0.028 0.057 5.446 0.355 0.147 0.048 10.810 3.509 0.166 0.454 1.518 1.007 1.590 2.133 0.051 1.105 3.136 0.395 5.433 5.905 3.291 4.914 1.302 0.639 0.981 0.001 8.052 0.925 3.010 8.626 3.005 3.422 0.168 0.500 0.112 2.368 2.467 0.053 0.183 7.481 1.067 2.478 0.090 0.075 0.456 0.337 0.560 0.148 6.449 1.374 1.516 0.920 1.060 4.809 0.034 2.412 5.059 11.054 1.535 0.355 0.166 0.341 11.792 6.837 1.828 0.198 0.387 0.401 2.871 2.603 0.265 0.692 0.136 0.280 0.105 0.044 0.873 0.000 3.487 0.256 0.069 0.425 1.383 15.712 5.487 0.863 1.021 0.318 0.615 0.558 2.071 2.464 0.000 1.863 0.579 1.605 4.270 2.008 0.347 2.593 1.881 0.397 0.740 0.324 0.524 0.144 1.834 3.600 0.397 8.555 1.015 7.552 2.034 4.646 7.374 0.519 0.109 0.518 10.998 0.489 0.306 1.426 5.219 0.422 2.326 0.420 13.250 1.271 2.581 2.950 0.797 0.435 0.072 0.292 0.637 15.382 0.416 0.163 8.379 0.011 16.842 1.226 4.712 12.668 0.029 0.467 1.756 0.086 0.003 0.249 2.843 0.142 2.819 0.380 1.924 5.525 0.300 0.023 3.540 1.319 9.637 0.000 0.380 3.548 0.371 2.343 0.058 0.593 0.540 1.078 0.000 1.444 1.419 2.493 2.119 0.414 0.607 1.084 3.592 0.040 0.794 1.017 0.233 1.110 0.680 1.940 0.358 2.883 2.990 1.773 1.078 3.093 2.186 0.592 13.759 0.425 0.021 2.158 2.258 0.302 2.656 5.052 0.385 1.111 1.850 0.693 5.483 1.146 4.407 4.817 0.406 1.129 0.408 3.444 0.108 0.111 0.015 0.059 1.125 0.278 1.325 1.463 4.045 2.183 2.436 5.590 4.411 3.322 1.670 11.919 0.360 3.491 2.701 0.739 0.292 3.474 3.414 4.009 0.258 1.436 2.333 1.309 3.518 0.659 2.040 0.809 3.517 0.777 2.312 0.336 0.418 1.036 1.263 1.198 3.369 5.708 0.262 0.899 1.528 2.349 2.909 0.719 3.045 HKI-272_14_IC50_uM 1.133 3.752 0.416 49.014 0.854 1.920 1.799 5.460 2.262 0.609 27.649 119.701 5.720 54.282 21.362 1.596 0.278 6.835 1.878 0.704 1.048 11.070 1.383 136.620 2.000 2.240 17.898 0.072 0.696 4.039 9.424 0.227 0.238 160.260 1.059 6.032 3.100 0.301 87.558 0.102 0.364 0.001 4.819 8.137 72.305 1.104 5.913 2.421 76.112 375.440 0.422 0.041 0.901 35.315 18.353 73.054 0.755 2.748 12.992 76.792 2.999 0.374 1.036 0.191 4.289 3.913 0.029 1.480 0.314 0.343 1.207 24.759 445.457 0.053 0.111 39.690 0.597 0.292 0.072 268.191 24.762 0.569 0.762 8.856 1.673 2.997 4.230 0.069 1.595 16.856 0.668 41.096 133.807 78.453 31.393 2.610 1.126 2.040 0.010 177.434 3.271 13.397 237.508 21.695 33.639 0.252 0.697 0.170 3.802 6.492 0.116 0.260 135.084 3.904 17.104 0.138 0.124 0.809 0.425 2.877 0.254 88.854 2.794 8.495 4.381 1.948 82.261 0.060 7.366 134.411 5202.528 3.900 1.121 0.267 0.503 310.754 278.997 4.062 0.289 1.053 0.893 19.469 6.623 0.455 1.136 0.271 0.626 0.163 0.086 1.255 0.002 51.193 0.363 0.163 0.704 13.960 387.610 49.809 1.200 1.698 0.705 1.452 0.826 10.759 6.062 0.001 3.909 1.721 4.465 128.368 4.740 0.553 10.592 4.008 0.545 1.848 0.616 0.850 0.791 3.519 30.667 2.244 277.911 2.818 183.938 3.096 24.459 313.782 0.728 0.194 1.051 703.101 0.944 1.190 14.695 105.151 0.899 12.942 1.244 255.111 9.693 4.109 6.438 1.745 0.937 0.158 3.124 1.050 408.626 1.350 0.584 190.776 0.037 484.443 5.237 14.466 282.167 0.076 1.229 3.058 0.138 0.019 0.489 67.249 0.939 7.866 2.507 248.912 88.199 0.591 0.093 60.202 2.067 230.880 0.0001 0.774 15.419 1.246 7.553 0.120 1.406 1.186 1.667 0.001 2.067 2.687 14.099 5.150 0.715 2.952 4.454 21.141 0.089 1.018 1.580 0.577 21.587 0.939 3.145 0.723 36.543 10.448 4.537 3.095 17.378 34.443 1.465 330.300 0.761 0.046 4.709 8.575 0.559 8.801 42.474 0.754 2.698 2.422 3.181 51.899 2.317 78.281 47.546 1.531 2.026 0.854 16.971 0.273 0.451 0.038 0.098 1.483 0.515 2.460 3.848 14.514 9.133 9.577 93.700 63.701 19.517 5.413 397.224 0.759 17.825 8.170 1.330 0.563 23.509 35.985 70.183 0.460 2.350 4.318 12.629 29.336 0.990 25.969 2.027 29.303 1.293 5.253 0.563 0.700 2.109 1.713 38.023 14.069 126.558 0.380 1.631 11.857 6.902 41.100 1.419 110.344 HKI-272_Bayesian_5pctCI_high 2.133 11.174 1.234 7597.694 2.143 6.140 5.867 27.591 5.257 1.090 2505.140 139232.434 38.471 14418.970 5023.087 17.207 0.413 19.812 6.084 2.352 1.454 1489.208 2.193 74272.794 3.885 7.371 400.935 0.132 0.979 17.992 1277.678 0.382 0.422 144929.109 1.560 26.264 26.065 0.807 378170.337 0.185 0.616 0.006 28.126 362.310 12632.145 1.700 1305.577 3.402 64260.473 104015.999 2.100 0.058 1.446 14579.912 754.987 18651.839 3.049 14.989 502.653 45862.359 4.816 0.721 4.794 0.313 26.089 115.677 0.561 3.193 0.887 0.531 2.161 7092.548 648553.644 0.093 0.218 3115.360 0.992 0.560 0.109 57866.852 2440.846 2.751 1.302 409.239 3.032 9.878 14.120 0.092 2.283 1098.279 1.093 5478.025 266279.024 142457.644 1467.184 6.837 1.994 5.848 0.057 63888.841 29.119 551.367 108271.799 4441.289 6133.372 0.370 0.963 0.269 9.842 78.445 0.256 0.375 131032.413 51.873 2043.052 0.216 0.210 1.484 0.558 46.284 0.425 36764.942 7.783 419.557 83.471 4.779 59213.214 0.102 76.112 82710.348 741000000000.000 25.396 4.770 0.418 0.740 73050.043 3042834.377 16.853 0.423 4.196 2.292 1787.727 58.265 0.826 1.977 0.553 1.488 0.248 0.157 1.877 0.035 55664.618 0.517 0.348 1.177 2357.837 267079.060 6182.636 1.667 3.309 1.564 4.617 1.220 666.273 58.387 0.004 15.876 8.607 35.153 205993.522 31.215 0.883 442.172 17.314 0.762 6.490 1.151 1.285 4.719 15.353 8306.553 36.966 1036955.942 23.048 89455.806 6.303 854.315 3703911.569 1.006 0.355 2.166 121874209.400 1.943 6.756 3543.251 69223.799 2.248 394.335 5.592 95025.447 441.289 9.098 29.589 5.095 2.419 0.334 343.401 1.840 183230.463 6.826 3.017 241759.812 0.097 114164.994 62.246 129.645 122773.933 0.174 4.612 7.817 0.219 0.070 1.046 125166.484 14.116 63.200 75.671 35980943.170 121236.686 1.128 0.314 95406.310 3.975 87264.586 0.003 1.355 603.472 8.476 86.367 0.244 4.070 3.064 2.807 0.003 3.244 6.942 665.874 34.035 1.132 65.287 63.536 1584.937 0.189 1.289 2.576 1.562 29463.279 1.231 6.172 1.627 12131.977 175.950 20.170 18.073 1496.823 51989.653 5.227 137296.761 1.463 0.088 22.545 146.306 1.119 136.510 8444.748 1.360 10.782 3.535 37.909 9372.171 7.985 62717.764 10705.362 11.551 4.633 1.626 800.391 0.739 2.762 0.079 0.159 1.923 0.894 6.396 19.158 227.853 194.942 233.901 27092.169 96028.471 797.674 42.119 1050734.499 1.949 820.981 101.261 2.654 1.090 2730.118 15246.420 95425.393 0.901 5.145 13.752 2885.346 7108.169 1.448 10322.693 7.719 6435.598 2.265 27.448 0.950 1.263 6.310 2.328 120764.784 565.212 320680.314 0.551 3.702 952.319 78.218 19525.957 3.434 795479.216 Cyclopamine_Bayesian_5pctCI_low 25.767 17.993 35.795 49.004 24.824 65.340 33.425 79.862 21.375 13.296 61.504 61.356 65.444 46.998 56.059 62.515 52.736 59.818 39.841 0.858 17.208 3.150 82.715 77.347 40.805 49.304 18.351 24.194 50.938 42.850 22.358 49.799 38.916 73.237 12.125 47.243 29.907 23.660 37.248 12.682 20.473 2.524 27.377 36.234 47.823 4.843 22.934 68.068 42.364 45.888 48.609 34.532 7.101 36.874 75.543 58.557 58.674 64.754 35.198 34.984 34.946 12.082 32.172 24.313 40.033 1.691 65.490 32.134 24.926 69.456 52.258 6.848 23.067 16.956 35.047 46.937 72.777 25.101 33.125 17.913 58.125 31.312 39.421 37.472 37.092 31.128 59.418 32.871 46.086 58.382 26.070 31.788 39.252 39.378 33.687 58.845 23.083 18.850 17.846 35.153 24.688 71.593 11.799 35.670 25.003 4.154 22.563 33.188 35.677 62.458 11.738 9.478 34.813 51.692 5.864 13.558 13.141 49.715 32.298 12.705 28.225 65.137 27.977 27.273 47.756 12.878 22.006 31.522 21.574 16.572 16.814 22.056 38.321 54.196 49.210 46.675 68.388 57.957 14.146 37.864 45.191 26.781 46.815 84.234 8.349 2.865 2.420 56.912 14.625 38.379 176.514 1.826 76.028 22.455 30.090 33.703 47.323 55.807 59.764 1.150 37.144 23.392 39.146 28.815 47.909 29.642 22.790 27.902 31.196 32.124 48.662 50.749 65.924 66.733 13.707 28.772 4.901 17.708 53.646 71.037 36.438 13.106 64.774 9.977 44.243 61.075 59.057 47.684 19.106 16.910 28.395 77.984 34.029 0.049 0.393 60.148 10.704 34.598 29.119 79.107 34.855 0.609 57.455 59.770 33.188 46.312 24.076 53.603 46.647 31.090 20.567 54.391 19.231 62.221 16.799 55.707 39.429 22.936 23.968 51.775 21.147 9.331 60.819 33.991 6.402 58.032 24.381 36.474 63.307 16.082 14.346 66.994 23.129 61.032 16.043 1.355 37.405 23.352 51.795 3.060 25.610 13.139 31.481 34.309 43.983 39.425 48.706 31.309 18.489 12.755 35.251 26.470 34.667 41.409 20.751 23.597 15.546 59.931 29.105 30.190 44.438 52.715 52.631 46.132 26.509 33.950 73.340 8.254 29.791 17.581 52.921 39.409 41.009 74.351 36.719 7.377 59.806 81.118 36.514 37.947 28.994 41.592 63.485 45.051 81.012 39.702 46.044 42.888 25.899 23.982 1.962 41.733 13.934 21.929 39.722 29.660 37.334 44.912 26.983 43.772 44.674 28.409 62.440 35.527 56.087 56.798 52.547 12.247 0.448 2.836 36.126 65.832 49.087 90.071 16.678 66.947 45.668 26.986 26.501 49.834 10.207 45.709 33.687 43.812 21.325 103.669 47.622 60.528 8.183 123.384 18.578 29.471 51.157 23.708 33.076 28.104 Cyclopamine_17_IC50_uM 252.497 108.245 774.022 934.676 294.477 1585.888 1183.936 2335.544 214.519 83.647 1488.613 1577.190 1695.614 986.734 1299.845 3232.464 1435.832 1686.482 582.250 1.930 132.887 97.339 2083.282 1630.268 746.130 1481.188 705.636 269.535 1110.094 950.606 405.329 8784.113 1287.941 1740.104 33.889 1103.122 973.697 238.889 1017.801 39.873 175.528 4.169 1137.286 928.899 2679.271 8.343 451.060 23026.477 1230.161 1300.495 1383.816 3081.279 58.405 2019.691 2239.706 1851.775 4770.469 1653.583 556.908 1038.051 1020.043 29.064 504.819 257.160 1130.596 16.927 1599.746 711.660 226.331 1980.293 1203.152 50.821 147.732 91.350 814.765 903.973 2392.514 515.378 304.448 385.715 1409.796 656.945 2072.270 1144.931 800.951 576.976 1358.994 225.495 1229.423 1898.463 239.104 289.977 964.780 1340.369 587.396 1252.629 302.808 146.043 343.195 1957.063 381.839 1996.398 257.006 754.006 221.539 30.202 189.237 411.784 717.161 1861.802 28.166 14.633 471.538 1475.423 19.933 35.216 38.134 1281.005 244.839 64.871 396.232 1745.506 248.415 333.419 1292.457 27.434 923.804 930.014 494.872 355.704 107.404 282.054 1339.833 1948.276 1831.334 790.843 2476.496 1200.748 32.418 781.488 921.405 562.449 1296.599 248599.886 13.452 4.533 3.857 3074.815 112.550 261.857 179584.297 44.563 447754.334 601.905 530.436 937.109 1723.306 992.275 1738.364 1.790 3367.413 194.669 793.934 545.389 2041.214 452.506 138.712 707.120 714.869 2835.859 1347.896 3808.916 1806.055 1940.304 39.682 348.835 49.181 145.445 1519.444 2020.095 896.233 66.043 1431.102 103.049 1548.435 1492.936 1413.324 883.684 113.398 124.973 584.759 89778.428 887.759 0.917 47.342 1995.400 33.629 1347.087 588.278 2051.856 770.084 1.492 3315.952 1508.695 857.225 893.637 501.950 4340.739 1253.130 321.051 113.932 1331.685 89.470 2195.577 116.082 2567.788 676.681 725.746 197.650 1277.040 91.368 22.120 5497.782 736.567 144.648 1507.940 864.456 1321.470 1588.110 124.948 155.804 1626.361 156.601 1568.225 220.412 3.104 1865.156 549.166 1384.923 4.364 390.919 41.137 287.810 893.905 1183.463 830.975 1176.148 580.042 329.014 693.256 919.013 293.477 571.292 749.645 80.302 408.953 406.222 1408.246 427.691 293.888 1053.318 994.062 1395.768 1303.620 346.367 1072.985 2301.462 16.310 342.715 41.484 2104.641 898.207 2203.495 1885.220 662.221 16.637 1590.812 2037.747 491.175 695.757 623.158 1056.905 1833.900 1180.390 2374.400 1524.619 1088.222 1094.552 352.130 217.979 4.242 1232.870 33.717 271.755 795.364 294.683 845.054 988.017 439.396 1136.945 718.453 246.017 2308.839 895.516 1448.234 1592.563 1429.672 53.796 490.390 5.119 825.591 1694.766 1197.391 2267.652 231.204 1705.989 1050.477 1095.756 1090.727 1290.907 21.572 1043.358 518.739 987.918 311.469 2334.143 1460.742 1336.086 167.838 104516.476 82.368 1812.931 1815.289 686.084 388.891 1595.113 Cyclopamine_Bayesian_5pctCI_high 59420.823 11073.388 406768.701 195457.843 77901.462 630709.087 13428636.000 592081.753 98498.835 7504.064 309093.779 375119.530 346556.104 396091.292 581170.818 20107430.880 629385.987 739034.586 92457.097 3.777 15121.911 117606.549 392974.499 269898.165 353804.578 1585800.682 13812713.580 76573.014 275763.805 400272.162 425108.624 223000000000.000 30210496.860 414695.585 401.899 329226.091 3454195.026 68857.883 624870.683 530.914 44618.328 6.308 27453384.080 1327622.093 224660290.700 15.676 650307.105 2970000000000.000 524132.608 1249932.365 487477.785 873308997.300 5037.172 272704677.400 608894.319 1199121.784 215527700.500 401916.647 231538.165 727813.418 442324.918 182.400 84990.945 140449.040 418528.388 917.635 329324.874 312512.579 20644.413 607009.670 527286.857 3324.252 15795.810 4756.655 722303.002 165578.387 1670109.916 525444.579 21239.119 978817.021 408971.193 323741.294 162957501.900 3177800.981 355187.110 476346.114 291006.243 8795.540 322577.921 1152449.229 39616.461 53690.964 717049.389 3245240.437 209651.100 241880.722 74854.387 28827.930 119419.765 101533565.900 221992.749 454885.037 525654.799 205931.733 20820.638 2161.808 30949.125 89652.826 498022.233 625808.692 271.619 33.589 72831.221 997193.388 340.972 355.349 500.847 515400.733 14892.306 2506.894 262288.416 528553.865 31048.321 59331.759 586718.250 156.272 15331191.940 16025632.030 1636057.595 91573.756 11888.181 93798.111 693703.559 1155796.183 21417095.150 257403.456 1715130.965 226318.822 172.173 440603.211 130600.719 172732.598 625183.196 626000000000000.000 26.592 7.117 5.768 71206879.930 12998.640 9282.628 1530000000000.000 20797.748 62700000000000000.000 1313754.991 229096.823 611029.183 21597756.470 106043.005 7781813.759 2.845 1079970972.000 39632.311 220356.066 1419336.405 47726626.130 194638.642 8015.240 510527.610 287161.484 2741031099.000 1513446.412 129423431.300 791353.461 586952.984 495.615 60210.377 14521.709 19281.474 640561.235 552882.069 637493.908 2916.385 373771.527 24931.816 2221515.103 444186.590 509354.746 173928.574 6751.365 17697.878 278312.538 9170000000000000.000 3343738.332 20.001 602172.965 974129.957 370.443 42588720.530 251726.888 575963.748 257609.461 3.689 1075767288.000 522249.123 2147038.481 238231.936 146502.826 458009278.200 676305.381 74787.048 6142.579 318793.871 2124.942 1542168.345 44756.860 58867516.860 399552.320 9873845.989 20952.222 2280716.030 3183.384 119.235 883145037.100 812036.038 183120.558 1564849.170 10569679.120 6575097.731 283849.657 42370.176 33877.285 274004.552 10114.244 3016476.541 93489.088 6.024 184821305.500 279288.339 471889.440 6.045 323514.754 1159.449 46723.382 3095933.394 2544131.774 198253.144 592674.131 654155.258 113936.893 7109198.025 274114.176 106617.186 214743.592 618591.254 2445.733 129624.877 557992.053 251550.741 626184.290 56246.551 265746.998 208042.986 609016.110 378813.773 130639.905 618158.391 734907.559 64.528 107087.336 193.079 5257152.036 732339.878 40491393.370 455841.299 671319.193 71.974 363778.338 414737.057 246594.360 1461830.536 263129.083 480941.058 998390.738 574066.200 1033642.986 5593971.176 309186.521 789930.306 92734.885 35939.779 9.225 6233820.842 254.907 102283.127 581810.458 112375.363 158847.516 238517.986 89241.370 503228.691 404052.460 18760.334 2605929.543 2355114.726 451170.231 407379.312 713544.441 2601.387 24029673.010 9.124 201914.577 394549.545 491245.853 788588.565 101265.393 315684.950 537293.619 12631446.290 36096266.610 954745.412 121.122 275185.309 123032.029 594930.577 353274.269 288427.779 402801.837 291559.681 112622.861 13400000000000.000 2588.671 171981935.000 1372850.784 597374.799 93367.631 458972108.300 Go 6976_Bayesian_5pctCI_low 11.599 15.597 1.895 66.773 7.859 3.219 9.561 34.405 2.134 0.321 65.320 28.017 28.039 17.032 20.134 10.157 22.897 1.980 1.394 0.159 9.903 8.907 27.118 46.270 0.901 0.414 24.856 2.463 5.578 48.000 30.027 21.533 20.122 9.512 0.185 31.059 38.229 3.631 37.766 2.285 1.347 0.644 17.775 13.492 60.238 1.316 15.350 30.597 26.060 74.277 14.188 0.429 1.660 49.660 43.241 32.031 44.150 10.955 7.643 38.830 26.848 26.536 14.568 1.786 49.650 29.336 26.770 0.047 1.224 2.204 4.578 17.907 20.446 0.796 1.324 27.755 8.179 0.384 4.105 43.229 15.893 10.619 19.747 2.427 0.364 44.199 8.526 1.382 2.374 58.674 5.433 60.479 41.821 27.134 26.104 7.523 13.585 23.467 7.668 10.533 16.913 36.082 0.752 6.659 42.709 0.117 1.878 17.681 9.139 22.658 0.286 4.718 37.483 0.778 30.045 1.330 1.226 1.463 0.716 3.940 1.829 33.023 16.018 25.536 15.513 2.114 27.622 1.279 21.715 10.554 72.096 17.939 2.757 7.718 3.180 41.579 14.344 4.584 1.817 0.248 6.096 39.841 1.471 90.261 11.303 4.973 2.348 7.535 5.853 10.312 31.243 58.586 11.186 5.833 63.739 8.435 101.799 49.210 4.413 4.409 19.181 2.533 0.017 11.528 62.753 0.818 14.265 9.306 22.637 50.481 27.841 36.514 18.401 12.564 6.451 30.855 1.367 12.317 11.144 79.790 53.613 3.249 45.796 0.022 42.250 18.165 14.261 30.469 1.499 12.739 6.281 73.303 2.519 0.345 0.182 29.421 23.282 7.851 2.949 11.976 26.361 0.184 21.641 10.267 5.974 14.904 8.932 40.805 58.522 63.390 37.229 21.033 1.209 68.142 31.019 36.922 84.200 16.829 41.588 26.240 36.948 0.321 2.483 23.245 7.694 43.702 20.506 52.405 31.387 1.860 1.883 30.963 30.057 46.834 0.321 0.004 25.257 20.878 52.947 2.318 0.909 26.552 4.174 11.557 1.617 13.281 32.015 29.791 8.617 2.453 26.883 43.047 0.114 24.648 17.948 13.643 15.453 14.082 9.088 8.972 28.157 44.265 2.426 18.638 6.482 9.151 4.063 13.070 6.327 5.540 45.345 14.704 10.732 4.018 41.297 0.925 30.009 30.609 0.592 30.864 12.252 42.581 32.937 8.627 0.494 0.815 51.656 14.165 2.646 18.675 0.784 2.622 9.255 19.888 3.010 36.723 17.930 35.670 34.274 49.581 25.498 34.274 13.359 0.806 6.594 43.030 49.122 18.445 0.012 6.302 53.941 1.545 61.338 23.658 26.269 36.463 0.316 17.097 25.259 35.030 0.802 21.861 0.241 4.606 16.735 4.776 29.192 33.778 51.542 5.956 22.531 1.272 44.478 40.613 16.161 42.212 Go 6976_19_IC50_uM 56.278 500.797 3.454 2169.604 35.023 9.657 43.663 664.543 3.111 1.038 1705.989 333.086 246.559 71.974 151.654 35.712 615.540 3.692 2.894 0.667 44.398 192.790 206.417 593.953 1.545 1.380 226.490 4.359 8.845 1445.051 816.233 907.778 93.382 45.842 0.736 336.938 1123.833 14.414 1008.279 3.651 2.526 1.785 113.807 71.902 1649.125 3.446 216.394 234.909 578.536 2352.891 132.383 0.635 3.825 1314.222 1076.855 697.150 2522.485 30.911 21.611 1310.547 751.597 273.199 68.505 2.449 1513.076 1037.532 319.514 0.491 3.250 6.339 9.808 238.483 140.640 1.766 3.046 334.889 183.571 0.620 8.841 1205.802 86.254 39.386 123.421 39.413 0.768 1233.240 21.002 1.720 6.202 2151.241 9.523 1342.918 929.549 588.749 194.397 19.535 71.229 242.500 117.085 25.154 138.698 648.784 4.513 25.307 725.238 0.219 3.374 94.983 26.991 349.813 0.584 7.399 895.785 2.481 777.746 1.899 1.703 3.547 1.082 14.391 3.161 611.552 118.831 320.923 84.487 5.165 483.379 2.618 442.172 207.805 76833.806 169.678 15.498 18.125 7.265 764.101 181.944 10.272 3.416 0.617 15.293 1007.473 6.850 5381.917 18.388 8.232 5.397 12.419 11.762 15.354 1050.793 2402.344 36.503 19.323 1973.374 40.053 31116.702 983.876 8.062 8.862 339.917 5.544 0.051 62.784 1765.696 1.767 45.728 197.453 391.741 1135.581 437.554 392.368 165.853 39.421 14.096 486.482 5.212 74.121 75.906 2270.374 1409.373 5.901 900.005 0.145 1065.820 88.721 56.205 229.178 3.307 58.446 14.862 2266.065 5.955 2.208 1.575 401.658 120.687 18.262 8.606 26.212 475.040 0.374 188.218 22.236 120.061 48.149 106.804 789.105 1591.130 4321.682 703.101 176.144 2.444 1744.808 779.615 353.753 4592.133 361.875 2970.543 355.847 580.680 2.115 9.511 281.913 1164.445 939.925 382.221 1527.366 605.467 3.595 3.408 656.748 395.519 889.803 1.484 0.081 192.020 542.832 1100.918 3.171 4.018 264.516 6.285 125.864 3.612 126.217 344.468 461.878 44.876 158.825 886.162 1069.985 0.430 170.034 73.906 107.426 468.296 30.163 25.229 21.538 655.698 931.131 6.732 188.500 19.711 62.197 7.302 28.586 9.901 11.978 4561.925 107.437 72.320 13.362 1836.102 1.578 492.995 246.485 2.192 303.263 63.181 1341.307 553.521 24.953 1.053 1.998 1344.261 69.138 8.047 119.069 1.567 3.965 14.449 188.821 5.913 541.098 233.364 730.260 812.162 1456.221 108.571 572.951 36.071 3.225 10.530 935.798 1121.363 189.256 33.271 34.261 1705.818 2.760 2238.587 179.972 670.283 924.359 0.560 320.506 295.243 657.602 1.639 116.653 0.408 10.328 95.135 6.131 648.979 564.929 31372.908 11.482 191.349 7.292 976.134 1432.677 53.689 962.082 Go 6976_Bayesian_5pctCI_high 1133.312 3457650.949 6.018 2186909.680 551.477 51.904 883.508 153261.363 4.490 3.680 707434.270 74406.605 34943.928 1303.489 23260.223 319.961 727813.418 7.318 6.701 2.362 1655.072 120644.080 26726.210 171253.467 2.615 5.795 45775.304 7.259 15.136 681260.474 623684.556 10454049.780 2772.210 832.139 2.863 73769.452 758880.804 182.254 847460.916 5.691 4.915 4.991 14139.110 2721.940 978621.277 12.050 198848.797 14095.347 460560.728 723459.612 25709.092 0.936 10.785 715187.482 626497.461 308661.350 1819085974.000 291.955 101.962 1361231.006 251399.855 67995.717 2302.613 3.326 592851.959 5993583.270 35699.787 4.312 11.230 24.811 38.004 163521.539 7514.577 3.969 8.442 84145.271 350459.350 0.972 23.444 1421324.868 5499.431 657.142 7851.815 7239.446 1.855 1372438.990 107.533 2.152 24.175 1571906.859 19.999 363051.509 389181.074 407705.346 14030.657 94.358 3523.112 23211.427 62454.902 130.883 31949.123 259652.636 66.760 309.358 317584.753 0.377 5.864 7945.015 197.769 146297.866 1.218 12.155 3007440.672 11.537 411350.118 2.769 2.430 10.602 1.646 141.684 5.260 286587.735 8441.371 97197.474 4868.300 19.234 96529.120 5.715 1117718.375 105155.975 6860000000000.000 43647.444 342.887 86.921 21.486 225844.051 51802.827 29.725 6.978 1.448 62.277 309464.914 72.595 19622746.750 38.920 14.556 14.208 26.441 35.075 27.699 4044222.996 4670141.832 321.469 201.724 1082301.121 1456.949 699000000000.000 423708.077 17.017 23.779 442944.607 15.100 0.111 2345.843 756380.625 4.034 810.864 465235.962 185386.850 254740.332 304278.902 72940.550 25944.113 419.054 49.889 182900.945 41.588 3231.171 4774.765 779727.673 561293.938 10.871 319911.604 0.624 316950.218 5013.051 871.486 28178.090 8.484 2685.977 66.162 775761.185 16.805 18.406 18.074 178974.748 5243.791 85.183 38.683 130.386 171133.631 0.705 14115.094 119.033 69668.252 601.604 49821.406 1147848.639 724980.473 57667251.190 1077441.708 36450.119 5.347 465422.093 3135502.480 29281.172 161158675.500 1351195.076 213895898.700 83416.382 263497.722 22.096 69.742 183725.854 158331263.400 287650.074 572976.510 377301.545 956656.814 7.046 6.020 356396.802 218076.239 447441.016 8.716 0.694 20266.002 357146.021 308877.489 4.370 31.174 56370.429 9.204 32627.149 9.448 17988.717 32656.526 236806.824 3709.306 807985.991 720931.929 275157.792 1.377 13702.040 807.062 16425.660 5093114.055 158.254 136.156 101.129 335675.433 288572.029 26.099 47576.775 162.943 6117.446 14.212 146.819 17.453 33.954 1026683971.000 9699.213 3881.589 84.352 18204875.490 2.803 404294.964 23694.542 11.208 62224.245 6302.490 1361775.608 166541.532 174.565 2.405 5.730 473117.949 5378.151 36.514 6928.510 3.242 5.856 30.326 36163.297 13.277 235885.076 66923.135 423538.628 304065.981 464445.732 1726.066 244751.821 195.390 19.727 20.162 355116.080 316696.759 57699.282 3779113.438 742.632 1072818.655 5.093 4675281.814 15209.872 341703.951 1184818.315 0.986 183102.247 122455.135 319591.853 3.544 5952.104 0.672 31.617 11896.506 7.591 207523.528 283169.235 4960000000000.000 28.740 36177.766 105.204 269197.341 686046.028 975.451 532373.186 Erlotinib_Bayesian_5pctCI_low 9.459 3.208 0.546 8.706 2.323 0.734 2.795 17.174 5.543 3.635 16.171 8.528 9.358 8.219 4.306 13.386 6.138 6.895 1.610 1.317 4.071 0.998 6.256 16.737 3.611 4.321 5.979 0.049 2.653 13.089 0.127 1.628 2.308 13.706 7.559 8.859 1.587 0.463 4.874 0.502 0.381 0.005 9.196 1.290 12.169 1.650 0.056 11.432 5.988 14.562 4.165 0.713 9.487 8.406 3.080 14.161 0.514 9.120 2.385 0.745 11.996 2.732 2.119 0.198 1.159 1.095 0.211 12.061 4.510 7.819 3.349 3.426 10.955 0.261 0.651 6.147 5.763 0.515 0.096 12.323 6.101 0.845 0.662 4.442 10.762 9.983 15.701 0.269 8.205 16.193 4.376 9.016 7.747 1.718 17.651 2.774 5.405 5.101 1.595 5.009 3.819 3.760 1.785 4.141 3.878 1.751 10.543 1.460 7.067 3.832 0.270 0.320 4.813 10.009 0.255 0.259 0.413 1.813 14.180 3.763 0.932 9.949 3.979 7.544 2.016 2.320 3.013 0.984 8.527 1.038 8.300 3.370 0.132 0.537 15.272 12.984 4.224 4.326 2.629 2.725 0.435 2.713 4.605 0.703 0.678 0.294 0.592 1.137 0.131 6.150 0.003 0.242 11.182 7.022 4.247 3.888 16.016 14.392 1.293 0.707 9.924 5.578 6.201 6.062 6.003 0.270 7.755 6.205 6.483 8.184 3.403 3.212 14.189 9.440 12.711 2.569 0.777 2.867 0.008 3.208 10.560 2.385 9.807 5.326 3.122 8.443 9.565 11.780 8.800 2.194 3.330 17.231 4.654 0.204 0.632 8.622 0.878 3.988 1.145 13.529 2.954 8.471 8.605 3.574 2.450 2.406 0.043 6.376 13.659 1.961 10.127 9.058 0.073 10.316 5.980 10.853 5.704 2.505 3.003 4.568 1.610 0.002 1.606 6.933 24.794 11.858 0.902 2.060 9.088 4.123 2.275 7.945 12.927 11.009 0.388 0.846 12.475 0.224 6.893 0.192 4.660 7.170 3.986 1.640 4.308 5.460 5.012 13.293 1.807 0.942 0.176 5.359 0.010 28.954 6.008 0.371 0.801 5.907 3.989 0.968 3.169 4.401 6.305 3.116 5.339 0.220 2.001 10.245 1.266 0.065 7.272 2.359 0.425 16.210 12.211 6.183 4.737 5.764 1.113 9.931 3.994 9.492 7.652 2.654 5.794 5.948 15.404 0.934 0.049 1.050 0.999 17.352 12.743 2.537 9.614 16.134 2.725 5.329 11.236 6.682 12.487 6.106 10.379 1.988 0.510 10.160 5.292 2.972 8.314 3.859 10.935 5.146 12.094 4.264 3.400 8.593 25.068 1.693 5.816 10.698 2.965 5.631 5.162 4.211 10.344 9.248 1.410 8.929 2.116 1.808 5.732 0.528 6.936 1.477 4.658 3.643 Erlotinib_1_IC50_uM 388.270 24.535 1.348 180.296 5.412 6.139 124.238 430.824 95.069 37.773 395.678 170.511 161.354 110.864 42.005 5941.994 123.483 194.280 3.120 6.514 23.425 34.292 121.900 469.233 18.903 58.915 513.269 0.126 7.188 353.506 1.037 2.510 5.205 282.337 110.819 164.712 12.648 1.314 316.588 0.815 0.676 0.017 3051.230 35.385 368.522 60.697 0.412 451.015 127.485 366.537 40.862 1.007 236.560 396.311 8.025 364.017 1.198 264.251 5.492 22.998 261.779 16.058 5.538 0.385 4.379 18.617 0.353 3055.199 66.493 184.528 30.594 241.363 329.936 0.569 1.623 52.499 134.680 2.438 0.224 904.516 106.378 1.697 2.521 45.769 262.881 232.479 407.973 0.380 174.269 399.574 26.340 513.064 141.231 31.766 417.006 6.468 109.695 168.545 7.665 30.781 75.740 21.525 42.940 27.771 22.437 5.262 336.467 10.515 88.226 121.596 0.586 0.483 25.028 314.977 1.369 0.491 0.730 2.978 4446.622 17.607 2.934 224.371 15.022 444.700 12.937 4.800 14.131 1.862 189.369 4.020 362.854 258.243 1.010 0.884 419.851 780.239 37.003 36.129 15.683 18.129 0.777 56.735 32.259 1.006 1.175 0.536 1.771 2.988 0.260 86.574 0.026 1.879 6671.500 130.347 88.252 63.542 1180.272 415.216 1.746 1.533 1533.794 1474.096 56.906 136.852 73.237 0.408 12100.475 253.585 303.657 1143.444 10.163 7.231 438.430 286.060 322.983 8.485 3.746 30.475 0.040 97.544 240.880 60.208 299.017 141.316 42.773 169.000 250.085 314.316 528.213 6.296 21.372 493.933 69.366 0.750 2.836 242.088 3.281 178.003 84.656 349.674 46.012 194.825 200.157 35.262 6.561 5.281 0.391 39.789 372.151 3.766 5163.655 188.011 0.134 924.174 109.169 948.517 82.179 28.867 13.394 101.616 8.499 0.037 2.177 115.631 18165.873 427.733 8.775 80.721 181.799 77.200 7.965 192.886 265.868 265.921 1.607 5.596 6801.511 4.952 169.610 0.497 218.897 117.085 18.515 1.927 16.021 1775.256 142.152 326.164 10.790 14.538 0.504 84.589 0.025 36355.472 71.615 0.953 25.234 59.086 16.037 2.315 30.384 49.491 183.846 24.881 98.101 9.270 7.765 172.898 2.762 0.120 225.586 6.962 2.156 389.748 977.991 148.934 90.913 43.384 1.917 199.917 67.282 278.551 176.073 8.981 399.934 1137.059 466.333 2.169 0.138 4.109 1.921 507.147 360.719 17.535 178.181 126766.235 20.363 119.989 285.831 171.949 311.158 76.623 201.140 5.343 1.894 305.393 98.672 15.900 179.756 51.198 265.841 91.022 369.777 31.877 21.622 242.233 140631.743 81.443 452.822 247.844 7.655 108.929 26.840 36.115 320.217 365.037 9.974 190.262 31.785 4.071 65.818 15.809 183.094 26.401 32.198 176.532 Erlotinib_Bayesian_5pctCI_high 2705236.778 4276.114 4.549 59361.432 28.025 371.779 1868226.233 118042.499 339015.124 8020.853 76803.078 101681.433 35592.848 18124.139 11888.181 10226006815.000 478685.938 809522.624 8.620 279.332 2387.495 112780.643 45455.995 214808.025 785.877 54600.592 160595606.100 0.294 65.582 93648.154 24.720 5.072 26.348 39735.489 62454.902 38326.621 1322.528 5.461 12072008.700 1.343 1.181 0.046 106000000000.000 76511.780 166558.187 327911.817 4.538 3146495.966 92392.400 75727.754 23148.841 1.384 124032.636 7015271.686 75.982 72395.542 3.586 120054.370 21.364 29013.021 80523.150 888.025 40.768 0.734 47.111 13784.499 0.575 896492065.100 18983.017 78299.774 6449.772 5749940.127 4726993.809 1.305 6.665 7334.907 211525.323 30.202 0.518 302623495.000 66582.696 4.033 23.430 19252.573 136379.947 57733.911 87491.769 0.539 203841.906 77761.366 2827.081 79957036.130 31882.100 21731.107 58624.032 37.781 372353.891 996495.597 313.469 2131.753 292055.754 2486.422 62274.045 2661.912 1420.835 94.415 441485.299 597.468 27512.618 225979.598 1.438 0.709 886.605 294696.119 18.116 0.941 1.286 7.201 24452541639.000 560.596 22.347 65381.852 250.185 78617116.430 1193.326 22.251 605.588 4.571 54573.298 54.337 14048132.120 44633711.740 18.294 1.500 237257.185 80825252.050 6072.344 5468.174 1124.507 2066.476 1.462 160219.495 3619.170 1.454 2.150 0.984 9.305 15.760 0.504 36399.124 0.125 54.647 27900000000000.000 25167.280 42736.131 17290.284 164677570.200 197698.812 2.423 4.195 9925767594.000 33259291213.000 7704.809 466307.236 25637.208 0.607 58300000000000.000 2753270.402 7816129.178 11061096841.000 167.151 33.003 218753.324 133399.011 62523.640 155.400 81.288 7241.618 0.141 499968.312 162787.346 100498.693 120030.361 80942.961 26338.842 209190.375 98203.781 213053.801 6594193.190 64.696 2061.935 148167.697 73931.924 3.838 34.688 206881.201 28.517 1283883.465 1938063.817 82967.148 18414.616 725198.000 245266.340 4785.759 55.230 24.752 4.752 884.392 109567.930 13.714 154000000000.000 66923.135 0.245 204831858.900 82092.341 3419294226.000 72831.221 8268.431 556.240 320712.384 143.811 0.290 3.161 41444.066 33282580868.000 1559849.656 1152.974 441176.367 80025.451 80660.156 181.435 242728.788 69863.597 100861.140 14.688 372.002 148000000000.000 2160.727 114404.993 1.432 1923967.465 23692.173 518.998 2.299 287.177 29436463561.000 1034159.937 206881.201 1139.449 13651.436 1.573 19631.683 0.052 274000000000.000 35291.591 3.062 65460.357 9077.009 651.775 7.721 11298.215 18549.535 129793.499 4321.250 41208.507 10478.701 83.321 32876.060 9.254 0.211 869522.944 80.778 35.139 85793.627 299492519.900 318507.085 77901.462 7026.191 3.923 31382.321 100629.426 100699.891 56517.183 132.489 55979717.750 3071402087.000 119910.391 7.148 0.385 49.640 5.068 409708.004 140196.460 1282.286 38735.044 123000000000000000.000 3262.340 33540.200 64055.169 134847.528 385694.159 18854.370 65874.059 29.952 12.498 221926.162 30607.489 673.912 86232.292 28082.447 83391.361 202622.516 251550.741 6656.173 2321.108 87168.648 735000000000000.000 732999.281 87776116.500 42924.584 66.786 42680.610 1046.284 6223.576 382965.429 844331.104 727.126 125316.774 25260.571 13.849 42774.611 22174.539 427923.620 38158.354 2614.165 1981966.318 Geldanamycin_Bayesian_5pctCI_low 0.120 0.049 0.021 0.547 0.046 0.181 0.139 0.096 0.057 0.00003 1.036 0.824 1.069 1.141 0.558 0.338 0.019 0.798 0.912 0.011 0.057 0.139 0.026 1.426 0.027 0.469 0.256 0.277 0.151 0.037 0.524 0.019 0.027 0.251 0.024 0.751 0.096 0.036 2.075 0.024 0.029 0.0002 2.072 0.479 1.047 0.002 0.073 0.029 1.573 0.570 0.608 0.001 0.025 0.346 1.621 2.706 0.539 0.465 0.183 0.396 0.392 0.032 0.136 0.008 0.100 0.444 1.405 0.022 0.195 0.018 0.112 0.482 0.489 0.0002 0.0001 2.405 0.019 0.089 0.025 2.240 1.662 0.173 0.042 0.184 0.038 0.323 0.216 0.022 0.375 0.575 0.009 0.531 0.502 0.161 0.457 1.681 0.088 1.034 0.027 1.167 0.085 0.299 0.195 0.063 2.029 0.014 0.040 0.296 0.061 0.054 0.008 0.217 0.086 0.015 0.222 0.017 0.001 0.475 0.025 0.00000 0.004 0.884 0.068 0.729 0.157 0.602 0.721 0.016 0.812 0.166 0.352 0.007 0.060 0.029 0.036 0.861 1.074 0.154 0.111 0.314 1.048 0.442 0.143 1.337 0.027 0.114 0.062 0.130 0.044 0.083 0.492 1.223 0.877 0.259 0.242 0.361 8.541 0.722 0.476 0.418 0.005 0.101 0.022 0.242 0.501 0.032 0.017 0.061 0.183 0.353 0.223 0.021 0.247 0.271 0.026 0.760 0.002 0.689 0.137 0.002 0.220 0.153 4.654 0.023 1.948 0.096 0.351 2.628 0.076 0.021 0.031 2.144 0.023 0.00000 0.000 0.459 0.553 0.058 0.505 0.121 1.100 0.069 0.134 0.614 0.047 0.198 0.043 0.032 0.780 0.642 0.026 1.551 0.096 0.646 0.219 0.130 1.974 0.276 0.035 0.270 0.046 0.043 0.129 0.486 0.974 1.005 0.248 0.048 3.501 0.0001 0.089 0.785 0.198 1.703 0.008 0.012 0.546 0.326 0.609 0.217 0.013 0.120 0.122 0.00001 0.651 0.092 0.108 0.128 0.154 0.432 0.638 0.136 0.008 0.012 0.157 0.108 1.937 0.023 0.409 0.113 0.358 0.407 0.053 0.013 0.160 0.210 0.042 0.336 0.254 0.021 0.211 1.479 0.262 1.724 1.578 0.031 0.030 0.979 0.297 0.234 0.001 1.520 0.234 0.561 0.029 0.012 0.268 0.049 0.688 0.006 0.001 0.186 0.030 0.068 0.410 0.475 1.407 0.346 1.301 2.740 0.550 0.136 0.549 0.079 0.068 0.681 0.00000 0.041 1.374 0.198 1.924 0.031 0.017 0.361 0.654 2.031 0.817 0.101 0.142 0.361 0.019 0.036 0.113 0.110 0.176 0.037 0.653 0.028 0.561 0.079 0.021 1.127 0.022 1.170 0.037 0.306 Geldanamycin_20_IC50_uM 0.224 0.105 0.058 0.841 0.080 0.351 0.300 0.192 0.110 0.001 1.896 1.276 1.533 2.317 0.898 0.569 0.035 0.991 1.142 0.027 0.223 2.735 0.047 2.472 0.041 0.836 0.427 0.568 0.300 0.072 1.376 0.028 0.092 0.356 0.037 0.969 0.297 0.085 31.019 0.036 0.048 0.003 18.634 1.507 2.573 0.009 0.191 0.046 14.306 1.425 1.197 0.003 0.039 0.645 12.198 49.289 0.766 0.823 0.340 1.196 1.806 0.064 0.381 0.014 0.252 1.017 3.317 0.040 0.345 0.049 0.332 0.834 1.057 0.001 0.001 17.800 0.034 0.169 0.041 41.009 10.138 0.440 0.081 0.636 0.089 0.567 0.619 0.031 0.680 0.982 0.022 0.648 1.503 1.288 1.063 4.473 0.323 4.955 0.104 2.396 0.275 0.450 0.732 0.123 9.455 0.023 0.061 0.408 0.106 0.105 0.018 0.306 0.182 0.027 1.185 0.029 0.003 1.156 0.034 0.0002 0.010 2.202 0.134 3.446 0.406 0.819 3.070 0.032 8.724 0.663 6.703 0.015 0.172 0.051 0.070 1.243 6.865 0.273 0.160 0.453 2.353 0.748 0.365 2.546 0.039 0.167 0.108 0.163 0.066 0.094 0.669 4.993 1.176 0.486 0.567 4.307 35323.368 1.030 0.589 0.800 0.021 0.199 0.037 0.561 0.751 0.067 0.028 0.161 0.696 0.537 0.495 0.041 0.628 0.457 0.039 4.740 0.010 2.619 0.252 0.006 0.439 0.410 176.003 0.065 24.167 0.199 0.489 14.983 0.158 0.034 0.065 18.803 0.058 0.0002 0.004 1.847 0.769 0.104 1.687 0.197 3.293 0.109 0.193 0.931 0.155 0.270 0.197 0.053 2.747 1.183 0.069 6.884 0.136 2.633 0.516 0.210 9.718 0.450 0.081 0.411 0.081 0.070 0.194 2.162 18.245 1.986 0.570 0.113 63.752 0.001 0.218 1.462 0.324 7.360 0.033 0.029 0.740 11.768 1.226 0.314 0.042 0.324 0.287 0.0005 0.816 0.217 0.241 0.226 0.251 2.525 5.658 0.315 0.029 0.023 0.200 0.371 42.914 0.033 0.566 0.239 1.651 0.555 0.086 0.043 0.319 1.112 0.076 0.496 0.353 0.030 0.400 7.220 0.556 7.969 3.828 0.049 0.061 1.539 0.547 0.443 0.014 13.592 0.384 1.255 0.051 0.023 0.456 0.111 1.628 0.015 0.006 0.261 0.043 0.157 0.714 0.806 11.805 0.580 5.545 61.020 0.762 0.261 0.787 0.140 0.100 1.167 0.0001 0.131 4.112 0.471 22.522 0.054 0.068 0.988 2.262 19.570 1.377 0.971 0.335 0.542 0.034 0.060 0.181 0.214 0.282 0.057 3.974 0.051 1.366 0.101 0.050 16.376 0.041 15.290 0.070 1.063 Geldanamycin_Bayesian_5pctCI_high 0.461 0.229 0.157 1.363 0.143 0.716 0.688 0.408 0.214 0.006 6.702 2.740 2.844 9.940 1.650 0.989 0.062 1.248 1.513 0.057 1.270 642.971 0.086 7.375 0.061 1.675 0.681 1.225 0.670 0.154 9.881 0.043 0.312 0.505 0.057 1.285 1.143 0.214 25923.366 0.050 0.076 0.013 3866.094 12.157 13.142 0.024 0.518 0.072 2871.816 5.706 3.699 0.006 0.059 1.249 1113.652 37227.388 1.093 1.583 0.688 8.635 51.218 0.128 1.349 0.022 0.751 3.743 22.285 0.074 0.636 0.127 1.374 1.733 3.501 0.005 0.005 2258.373 0.059 0.336 0.067 113834.396 1190.823 1.378 0.167 4.304 0.223 0.998 3.020 0.045 1.276 2.045 0.047 0.759 10.753 55.020 3.674 32.806 2.092 104.931 0.558 15.022 1.234 0.657 7.555 0.246 380.125 0.037 0.088 0.558 0.194 0.218 0.034 0.434 0.449 0.046 18.683 0.049 0.006 4.566 0.048 0.009 0.019 17.008 0.284 80.842 1.256 1.153 79.432 0.059 2389.406 5.626 5357.218 0.028 0.544 0.088 0.143 2.218 400.374 0.536 0.234 0.618 11.274 1.498 1.099 9.215 0.056 0.246 0.200 0.202 0.095 0.107 0.848 282.534 1.855 0.809 1.725 605.709 70200000000000000.000 1.584 0.708 1.871 0.072 0.435 0.059 1.755 1.143 0.150 0.044 0.492 5.891 0.767 1.313 0.076 2.204 0.715 0.056 201.926 0.025 34.921 0.479 0.009 0.874 1.331 2067188.439 0.201 9350.639 0.464 0.665 474.234 0.362 0.052 0.152 2529.811 0.147 0.005 0.065 20.658 1.066 0.188 27.306 0.329 60.226 0.177 0.271 1.588 0.641 0.367 1.398 0.088 35.019 2.856 0.182 265.948 0.192 34.921 1.548 0.370 597.647 0.684 0.190 0.607 0.149 0.115 0.298 27.445 49202.514 6.946 1.512 0.278 31662.871 0.003 0.518 4.794 0.536 423.054 0.115 0.062 0.956 18556.956 3.458 0.471 0.114 1.059 0.772 0.004 1.001 0.572 0.612 0.401 0.408 65.059 599.622 0.868 0.088 0.040 0.255 1.637 28017.932 0.046 0.755 0.574 32.707 0.709 0.129 0.135 0.665 19.729 0.141 0.696 0.489 0.044 0.789 287.666 1.344 339.679 25.391 0.078 0.130 3.213 1.153 0.906 0.117 4078.971 0.608 4.136 0.090 0.041 0.698 0.276 7.565 0.029 0.019 0.380 0.059 0.408 1.377 1.549 1850.294 0.942 193.795 84838.099 1.034 0.544 1.124 0.244 0.148 2.812 0.001 0.480 72.610 1.354 6717.693 0.093 0.247 4.251 45.869 3789.161 3.080 49.333 0.870 0.770 0.059 0.100 0.298 0.442 0.446 0.090 224.438 0.086 6.168 0.130 0.114 14256.953 0.073 3765.365 0.140 8.338 AZ628_Bayesian_5pctCI_low 1.402 3.642 1.561 5.720 2.169 2.721 5.490 0.800 0.582 0.045 3.759 3.659 0.850 3.533 4.805 3.382 2.220 9.461 1.902 1.415 1.078 1.067 0.145 9.218 0.542 6.161 0.157 1.379 2.594 8.315 1.584 2.577 3.916 0.199 3.353 5.592 5.844 4.061 4.290 1.300 2.033 0.262 7.615 3.062 3.669 1.004 8.660 2.950 0.448 1.221 2.298 0.999 0.069 0.196 3.153 7.433 6.266 0.225 3.184 9.954 3.770 6.982 1.504 0.545 2.492 1.435 7.772 5.266 2.541 0.158 1.218 5.696 2.535 1.078 0.888 0.997 7.815 1.313 1.610 17.879 4.899 1.418 0.480 2.163 2.413 4.869 4.171 2.472 0.262 3.135 0.941 2.642 4.048 6.070 0.001 3.408 4.394 4.054 2.515 14.060 6.053 10.214 6.295 12.664 0.963 2.539 1.667 6.537 2.735 0.002 0.392 1.069 2.728 2.819 2.318 0.952 0.702 1.310 2.442 0.984 0.484 3.269 1.608 3.856 0.216 1.340 3.665 0.670 13.651 0.545 2.669 0.909 1.977 0.664 0.826 5.272 0.274 2.279 4.324 1.471 2.697 4.205 0.193 3.007 6.673 3.142 4.619 1.115 5.745 7.353 1.080 4.138 4.914 2.597 9.107 2.199 12.384 5.785 2.464 0.792 3.102 0.023 8.599 10.315 2.576 0.065 0.063 4.542 3.594 7.014 11.693 2.875 0.512 0.438 2.744 2.910 0.164 5.619 4.763 10.207 2.649 3.936 5.035 2.753 2.208 8.009 4.135 4.873 0.945 0.157 7.881 4.635 2.374 2.308 7.806 5.890 5.883 7.895 3.695 14.965 5.520 0.405 5.700 6.447 3.270 9.308 1.228 4.936 15.339 3.261 8.495 1.099 2.460 10.240 6.673 4.549 10.206 1.174 0.873 6.894 1.369 0.258 0.481 5.341 3.451 4.070 2.939 5.098 9.254 4.543 9.066 1.995 10.701 4.693 4.383 NA 5.157 NA 2.627 2.694 6.703 10.020 2.369 6.577 6.406 7.254 1.658 14.188 4.308 2.225 3.919 2.722 2.429 3.876 7.553 2.672 5.998 0.259 4.573 2.621 3.993 8.449 0.400 0.430 0.421 6.495 1.577 4.079 1.489 0.497 12.718 2.201 4.234 3.359 3.255 1.378 0.219 2.932 3.885 6.156 0.266 1.464 0.011 5.626 0.223 13.834 7.290 8.124 0.813 0.548 0.658 2.418 2.693 3.622 2.474 4.265 3.584 8.249 3.401 9.176 10.597 3.348 8.192 2.251 4.208 3.314 0.216 0.736 4.248 2.842 3.814 2.862 4.081 2.798 5.146 7.715 0.978 5.389 2.846 5.736 1.066 3.737 1.888 0.541 5.941 0.162 9.996 3.532 11.691 2.991 1.430 3.563 0.078 1.423 0.764 6.667 AZ628_29_IC50_uM 2.941 22.426 5.279 76.440 4.615 20.383 57.882 1.674 0.908 0.113 11.153 13.210 1.775 13.893 55.673 13.028 4.420 202.796 2.934 5.250 1.854 3.722 0.300 251.917 0.947 133.300 0.338 3.034 5.048 184.122 6.717 4.400 18.064 0.343 10.120 43.904 101.962 11.109 141.670 1.740 3.751 0.490 371.816 24.158 15.535 2.732 201.482 9.392 4.771 7.857 4.921 1.406 0.112 0.624 10.642 118.771 122.904 0.435 7.411 353.364 26.621 58.469 3.421 0.810 12.779 2.576 230.074 158.491 18.397 0.436 3.589 145.053 5.079 1.777 1.467 3.446 207.701 2.110 2.516 485.850 38.027 2.106 0.829 32.343 7.635 83.530 25.031 3.572 0.405 12.671 1.500 13.865 24.361 119.510 0.013 13.902 39.279 117.214 20.225 481.738 199.437 231.111 163.465 358.203 2.070 12.043 3.068 189.483 6.716 0.031 0.601 2.120 5.409 19.022 34.998 1.376 1.081 2.108 5.493 1.879 0.904 17.145 2.473 34.946 0.706 1.957 8.173 1.095 378.607 1.303 48.935 14.174 3.592 1.158 2.491 35.605 0.504 5.646 25.144 4.603 6.867 72.385 0.285 13.547 306.249 13.144 73.156 2.536 148.681 170.119 1.688 26.605 79.480 3.609 358.239 26.068 304.144 57.564 4.143 1.152 58.534 0.051 140.597 335.157 25.467 0.258 0.169 77.401 16.064 250.611 255.290 5.610 1.231 1.263 6.232 9.480 0.437 111.687 188.500 301.178 9.088 33.149 38.815 11.570 3.922 119.402 118.297 83.999 1.314 0.234 196.468 59.057 7.547 4.460 189.900 189.010 157.323 197.354 119.953 365.512 55.841 0.963 79.265 101.606 7.386 278.133 6.826 92.287 351.919 11.936 3207.670 4.647 18.058 232.502 124.052 15.316 196.448 3.670 10.170 68.827 2.066 0.789 1.785 66.387 23.005 46.169 42.786 24.410 184.639 23.373 185.453 4.804 253.966 41.446 17.032 NA 109.925 NA 9.372 4.150 205.080 239.439 5.206 117.050 22.771 249.685 3.186 398.776 86.401 5.279 72.385 6.596 90.523 17.341 126.078 11.637 262.146 0.360 16.310 5.112 42.777 220.170 3.397 1.017 0.997 141.812 2.766 10.532 2.428 0.831 343.092 20.436 16.732 11.599 17.709 5.046 0.478 9.950 24.814 73.450 0.653 9.468 0.029 126.545 0.418 419.809 150.145 131.618 1.883 1.197 1.086 5.043 19.761 19.395 4.497 49.014 42.233 239.511 15.199 312.061 280.115 11.722 358.884 9.456 32.763 20.075 0.436 1.610 22.619 9.996 37.860 11.970 16.939 8.918 104.032 166.052 1.556 165.670 10.391 71.343 2.005 82.401 2.619 0.927 96.815 0.293 275.945 11.314 185.008 5.290 3.195 61.002 0.161 4.074 1.241 216.048 AZ628_Bayesian_5pctCI_high 10.468 2839.548 144.041 59083.088 23.352 3690.067 8615.343 4.792 1.362 0.298 107.781 266.934 4.295 336.905 36159.681 382.987 18.296 323385.374 6.263 98.347 3.903 47.928 0.661 574525.637 1.625 65336.100 0.779 12.197 20.695 219344.756 148.636 12.966 768.699 0.570 101.942 2705.927 37485.145 68.238 885581.703 2.389 13.798 0.902 32976310.570 7482.334 267.441 18.216 125517.441 264.145 324.213 489.067 25.883 1.877 0.188 2.510 149.127 215518.062 289670.689 0.887 36.089 1182096.364 3771.771 12983.051 15.424 1.198 798.632 6.239 110128.154 1923005.722 2006.405 1.337 27.658 822990.552 20.061 3.122 2.506 31.709 133412.352 4.289 5.290 91253.808 3561.012 3.372 1.503 23782.374 93.494 20375.735 1291.681 7.083 0.640 481.353 2.595 615.909 1692.057 77675.875 0.058 460.080 8893.714 376849.054 4007.408 736452.486 5385388.442 82133.397 114702.833 222392.696 6.238 745.832 9.974 1166012.073 46.871 0.204 0.893 5.387 21.308 2026.570 16139.097 1.847 1.540 4.000 30.314 4.737 1.765 1167.477 4.387 5980.144 2.783 3.236 34.254 1.700 182079.740 3.926 31688.211 5090.850 9.602 2.171 14.869 2528.041 0.967 44.492 1565.718 80.022 61.246 33176.597 0.412 345.814 25135707.430 668.342 65801.637 9.667 48864.185 376397.107 2.763 1728.657 70664.599 5.793 2906325.132 11713.532 62931.367 7731.823 12.022 1.559 118314.309 0.100 39791.158 612865.023 4903.478 0.825 0.413 23599.953 771.472 788194.369 72991.626 19.925 3.453 5.189 32.838 138.144 1.008 24723.265 5433532.321 138275.037 133.740 6775.714 3324.917 299.825 12.339 44391.354 66085.194 51400.337 1.750 0.365 132932.931 39336.181 84.226 13.947 349934.055 11194128.970 203923.459 227248.634 1863188.825 83616.822 14294.069 2.845 35372.855 103694.048 35.009 371238.503 345.433 220091.798 64003.945 162.325 8954302679.000 77.781 3086.521 52292.069 91573.756 183.791 40352.152 28.706 2059.050 10062.793 3.633 2.873 14.365 15424.308 1738.364 10296.919 64711.875 738.780 49553.095 1088.984 26307.254 22.746 60979.926 8204.188 416.672 NA 47178.804 NA 286.489 8.800 4403454.921 112274.270 28.916 29542.938 213.620 1129177.444 9.782 707929.648 48208.952 72.356 132720.408 43.237 80482.899 785.955 35875.145 418.342 10405031.030 0.503 325.024 26.645 7837.694 94315.422 178.039 2.658 2.812 52585.726 6.385 52.815 4.971 1.409 115208.637 4415.163 307.385 261.988 1905.501 66.188 1.039 103.110 1079.011 22216.710 1.817 536.894 0.062 464445.732 0.749 166741.502 44533.634 41864.772 5.609 3.143 1.658 19.633 3132.855 873.406 13.565 37722.047 16880.257 128823.689 647.488 118219.696 550509.780 223.274 5799602.856 376.832 3737.978 2040.398 0.923 4.150 1061.459 184.049 14301.218 361.369 333.519 141.147 34842.737 54940.167 2.681 159213.285 258.372 9446.504 4.375 98292.205 4.538 1.500 36658.478 0.544 78519.321 184.067 31818.399 14.322 12.065 59557.648 0.307 35.531 2.023 167963.169 Sorafenib_Bayesian_5pctCI_low 0.571 4.253 2.239 9.585 3.463 8.770 3.512 8.631 0.398 0.056 13.204 9.371 4.177 7.052 11.396 9.814 0.111 2.788 1.906 3.102 1.379 3.722 4.318 4.388 0.908 2.080 4.427 7.594 1.650 12.847 1.786 0.476 2.592 13.998 1.872 16.853 14.395 3.450 10.132 0.388 2.318 0.804 12.191 4.567 3.542 8.535 13.307 0.910 3.846 2.011 11.201 2.480 2.519 10.728 2.410 16.125 6.349 7.601 5.687 11.665 1.352 18.905 1.838 0.396 10.412 12.363 8.876 0.885 6.236 0.312 0.459 5.867 0.829 5.836 0.297 0.958 0.174 0.920 1.593 14.769 3.246 3.632 1.302 0.279 0.823 7.364 12.224 0.774 0.536 2.147 0.276 4.762 9.315 12.979 4.786 1.893 11.446 2.010 2.928 14.718 0.777 11.761 9.824 11.467 1.082 1.976 0.715 10.196 1.345 0.326 1.123 6.101 6.596 1.664 7.472 0.557 0.744 4.941 0.226 2.169 5.287 13.497 4.055 2.903 2.687 0.661 19.735 0.295 4.831 0.489 9.602 0.264 9.122 6.750 5.811 20.154 4.688 2.203 3.249 0.785 6.723 4.976 1.233 6.093 13.176 3.694 5.125 6.631 10.137 2.964 11.493 6.575 6.244 19.461 1.614 3.966 20.330 1.822 4.706 0.440 3.289 1.128 0.651 8.984 6.773 1.865 0.152 1.856 3.507 6.107 12.880 1.861 3.364 3.110 0.600 1.785 0.312 0.510 0.358 7.575 10.054 9.721 10.166 8.181 7.868 3.676 6.085 11.957 2.400 1.756 0.635 8.078 0.518 1.397 9.093 17.568 7.968 8.796 0.265 10.870 3.651 0.435 4.460 4.627 6.908 6.780 6.525 11.097 1.804 8.791 15.099 2.388 2.740 3.436 10.021 3.537 5.134 5.317 6.031 5.773 6.066 7.338 0.840 5.827 11.465 4.440 11.176 14.365 8.621 8.339 3.620 3.472 7.775 13.523 3.845 NA 0.933 NA 2.550 25.922 6.370 5.374 3.248 10.228 13.799 0.871 6.613 15.666 8.444 8.846 7.650 8.063 5.054 0.467 1.288 0.959 9.923 2.549 3.210 2.779 9.196 4.621 3.025 1.354 9.737 9.062 1.457 5.314 3.487 3.015 2.774 2.774 6.042 4.251 2.081 1.699 3.704 2.453 1.172 12.450 4.687 6.839 1.230 2.117 0.524 0.649 9.633 7.126 0.928 4.745 0.433 5.073 12.920 0.451 1.200 16.425 8.763 12.682 9.670 5.499 10.908 1.218 14.020 11.003 5.251 7.955 12.480 1.188 4.923 6.392 6.579 1.481 3.574 5.285 4.052 7.357 1.513 3.105 2.505 0.645 8.172 2.766 0.787 5.344 13.241 6.362 7.810 3.289 8.246 1.565 6.304 11.983 1.978 4.785 2.894 7.618 Sorafenib_30_IC_50_uM 0.835 26.541 12.024 203.751 22.536 232.223 19.453 176.602 0.578 0.103 305.515 203.243 15.387 190.986 470.737 244.594 0.401 5.439 2.834 38.990 2.204 41.030 26.021 21.415 1.327 5.160 27.991 177.967 2.341 327.471 4.278 0.649 5.654 435.415 2.654 379.859 537.377 7.347 324.018 0.557 5.862 1.176 283.894 75.061 10.542 238.126 352.271 1.208 69.214 16.492 367.896 4.300 7.300 288.069 4.612 528.847 187.223 165.670 106.976 348.173 2.045 733.626 3.336 0.572 318.620 337.613 243.813 1.234 150.370 0.486 0.797 200.718 1.134 93.140 0.428 2.381 0.279 1.358 2.591 404.236 12.694 10.945 2.076 0.660 1.201 193.853 318.907 1.036 0.720 5.123 0.404 77.750 231.759 503.408 40.427 3.349 262.907 7.105 20.174 520.870 2.400 332.720 332.354 380.125 2.172 7.218 1.124 629.484 1.800 2.400 1.912 125.474 74.993 4.400 247.126 0.864 1.111 44.930 0.314 4.673 82.475 335.493 27.891 129.425 10.563 0.978 550.265 0.435 59.015 0.923 848.525 1.038 174.600 161.467 200.157 489.752 87.392 6.031 15.295 1.653 121.280 93.728 1.846 168.494 433.547 13.180 107.609 192.174 309.699 12.598 287.493 119.522 145.010 734.801 2.837 79.870 667.607 2.624 38.826 0.659 19.315 29.675 0.923 327.046 159.286 4.626 0.279 9.159 18.477 190.471 302.748 2.489 26.060 30.898 0.924 3.102 0.494 0.884 1.365 293.800 266.427 259.563 323.080 184.085 172.483 9.838 190.033 314.222 4.863 3.907 1.217 204.507 0.852 1.871 227.102 419.389 181.019 177.772 0.859 229.018 16.695 0.825 77.657 59.205 101.251 147.452 195.195 342.407 2.634 146.804 399.415 9.751 17.383 10.604 232.200 12.953 57.754 92.657 321.340 34.588 44.536 162.520 2.284 119.797 1327.695 60.740 346.506 1768.700 152.964 227.011 21.065 13.274 140.092 338.018 17.572 NA 2.126 NA 9.211 688.076 127.702 58.422 13.183 317.253 332.487 11.493 126.204 975.061 260.551 162.049 252.472 144.085 176.197 0.640 1.752 1.532 264.621 4.308 6.114 5.493 265.841 38.027 50.436 3.288 263.908 304.326 1.988 30.855 19.896 10.570 11.161 23.941 79.265 20.239 4.038 7.178 34.754 3.813 1.575 2106.114 82.376 170.989 2.107 5.145 0.859 1.042 235.474 148.859 1.502 26.910 0.701 41.984 343.504 0.654 1.618 485.122 256.929 372.784 206.665 112.045 1329.423 1.746 420.818 312.311 71.923 194.222 312.624 2.451 39.599 125.939 174.060 2.472 12.236 67.000 61.313 148.829 1.937 45.381 4.777 0.957 122.842 20.134 1.088 74.054 350.935 102.699 223.497 8.559 67.215 1.982 80.078 343.539 5.018 81.957 6.627 276.193 Sorafenib_Bayesian_5pctCI_high 1.183 1780.768 724.586 79102.519 3170.359 68692.823 1371.280 40994.779 0.831 0.192 63754.816 143817.441 277.772 1509365.618 3787057.915 57710.823 1.733 19.506 5.594 9891.193 4.455 12661.232 2096.239 765.018 1.798 43.185 2170.472 130157.430 3.828 157581.805 30.898 0.891 34.550 238351.082 4.839 59468.379 432354.010 34.536 215582.727 0.799 57.535 1.620 100599.242 65094.803 106.314 152116.203 71546.295 1.519 71625.039 3116.606 250571.603 13.347 80.270 104192.976 20.432 308075.450 7937429.180 136502.745 791986.797 149387.667 3.772 642036.221 11.556 0.813 213096.416 181588.787 56505.881 1.591 141322.529 0.778 1.307 1180442.587 1.521 31476.610 0.639 11.082 0.446 1.886 6.201 129365.887 438.518 124.574 3.998 1.353 1.656 73467.617 91171.716 1.311 0.990 32.737 0.604 87194.802 118681.653 305957.046 6800.830 10.099 70813.150 102.956 2791.125 396923.958 14.729 126108.762 312044.162 170041.873 6.353 138.976 1.639 35740676.650 2.456 102.760 3.886 1347417.021 7731.050 38.737 114244.938 1.236 1.528 7328.308 0.424 21.098 30445.699 93891.956 2721.123 563374.572 407.932 1.353 115162.563 0.666 14716.138 1.582 386599565.200 7.434 59527.877 629637.792 1476079.287 110790.909 188282.731 85.524 792.110 4.317 35543.053 47791.353 2.962 689967.656 919237.683 278.356 414654.118 294696.119 203129.706 362.455 117677.134 125492.340 91546.288 3669991.852 7.789 74757.140 184979.447 4.954 6508.082 0.985 863.764 132309.612 1.259 1808846.668 143702.433 31.801 0.479 531.498 1025.361 322771.525 69933.495 3.872 5895.237 9032.640 1.308 8.991 0.786 1.431 7.124 1993893.863 142828.516 582392.559 1581999.324 99827.602 109043.264 84.563 62611.234 130235.548 23.423 26.396 2.465 83717.223 1.368 2.660 228022.594 56246.551 46323.284 102621.219 3.076 49182.837 633.335 1.676 141435.633 44435.768 18553.245 54874.278 78763.109 244531.643 5.168 50332.184 123229.038 260.135 1992.011 117.637 228182.266 298.211 12472.731 82826.224 25699960.170 1287.168 3287.886 35450.761 11.729 224560.402 3153566905.000 15328.973 300589.252 60155577405.000 44604.945 379230.698 1190.585 235.969 37522.649 61028.729 652.623 NA 8.055 NA 257.830 113686.507 151342.385 28632.565 425.430 220753.064 76780.041 3453.695 47978.103 60285369.270 166791.532 29821.951 357431.852 61734.610 113311.960 0.896 2.449 2.647 217640.522 11.147 21.970 21.999 96480.867 2736.404 27140.979 20.683 76267.334 272474.415 2.967 1237.811 1885.409 329.277 262.513 3921.776 12327.650 926.765 14.884 162.033 8959.771 8.698 2.055 4860951317.000 29998.420 61199.849 4.481 46.196 1.370 1.508 91335.973 233537.980 2.529 1510.959 1.091 7488.322 76710.970 0.953 2.206 217118.811 147871.658 102017.536 36235.696 33272.949 19908248893.000 2.606 282575.203 87395.581 27479.622 94901.994 61512.765 7.761 3285.256 149119.011 170791.706 5.199 201.663 12719.608 68589.861 59688.819 2.539 10368.213 17.725 1.314 42881.681 2044.278 1.415 14450.727 116856.270 31583.812 87037.993 69.623 4528.744 2.645 12215.977 155702.124 43.000 39890.760 37.826 543562.514 MK-0457_Bayesian_5pctCI_low 1.335 5.562 0.198 7.361 2.018 3.890 6.472 3.890 0.976 1.226 6.699 4.621 2.282 1.177 0.456 0.173 0.020 0.898 2.708 0.146 0.598 3.308 0.883 13.934 0.248 5.909 2.487 3.370 0.773 4.454 2.027 2.283 4.487 4.819 1.337 4.208 1.309 4.012 2.519 0.293 0.351 0.038 0.359 5.985 11.282 1.179 3.124 10.643 3.530 0.117 0.151 0.150 0.356 0.060 3.857 3.295 4.927 2.755 4.904 4.331 4.811 7.371 1.240 0.883 7.591 2.766 6.243 0.041 0.195 1.143 0.585 0.176 2.421 0.347 2.100 0.110 4.566 0.080 2.909 12.427 7.154 3.519 2.184 0.001 3.044 0.526 2.102 0.999 3.439 4.869 0.639 0.587 5.225 6.667 2.195 0.740 3.234 6.975 2.101 10.060 2.518 11.719 0.675 0.549 0.574 0.038 3.172 0.819 3.249 4.503 1.060 0.150 5.819 0.705 2.731 0.267 0.207 4.538 0.562 3.374 0.593 6.057 4.171 2.093 3.143 3.813 7.069 0.407 6.700 3.102 8.751 2.673 2.849 0.121 0.479 5.582 4.729 4.201 0.170 0.309 1.237 1.696 1.976 1.423 3.548 2.342 3.647 5.276 0.135 0.571 3.907 3.293 0.805 0.110 0.044 2.065 9.373 1.061 0.256 3.554 5.029 1.580 0.072 1.667 3.647 11.062 2.937 6.088 3.460 3.529 0.205 1.957 2.704 1.299 0.102 3.251 0.069 0.552 0.330 0.137 1.807 1.980 2.496 5.793 1.664 1.057 2.381 1.534 3.169 0.180 0.752 2.794 0.256 1.216 2.867 5.688 3.151 5.003 0.774 1.131 7.340 2.243 5.585 1.977 6.154 2.681 3.834 0.710 16.035 5.293 5.622 1.840 0.359 7.436 3.828 1.797 7.277 4.103 5.015 7.094 1.148 0.188 0.379 4.396 0.163 5.472 1.270 66.340 6.928 0.238 3.357 8.615 1.469 1.217 9.429 NA 0.157 NA 1.981 5.424 5.893 2.987 1.971 1.653 3.147 7.231 5.241 3.467 0.193 0.431 3.378 5.374 2.011 2.316 2.215 3.674 2.439 0.296 2.616 1.745 4.582 7.465 3.064 0.293 6.978 4.834 10.946 5.271 2.075 4.885 2.474 3.137 1.267 3.593 8.911 0.047 0.606 3.519 4.855 5.054 2.042 5.728 10.064 2.863 0.183 0.093 0.076 1.158 7.360 3.724 0.065 10.619 2.272 2.775 4.134 2.688 6.930 8.978 8.408 5.888 7.935 1.415 4.951 2.158 0.099 4.841 1.880 0.508 7.442 2.821 2.445 1.007 4.511 5.809 3.978 5.647 1.457 4.832 2.578 2.285 0.641 3.965 1.421 1.817 0.077 1.381 7.709 4.828 25.023 1.101 2.279 2.447 1.930 0.027 1.621 2.722 MK-0457_32_IC_50_uM 6.090 118.250 0.667 139.575 6.595 22.247 109.651 18.123 2.767 7.006 119.701 40.153 5.491 6.950 0.938 0.363 0.072 4.982 6.341 1.152 1.629 160.678 2.047 8510.024 0.423 113.818 5.822 18.782 2.977 18.445 25.700 4.292 21.611 103.379 3.291 21.665 7.274 11.748 45.191 0.658 0.776 0.119 0.767 209.118 419.096 2.268 97.514 177.346 41.788 11.996 0.620 0.237 0.815 0.151 31.849 20.312 49.402 18.368 22.785 107.997 100.836 69.338 3.289 2.557 204.220 9.008 212.853 0.071 0.693 6.457 1.450 0.778 7.183 0.725 15.963 0.582 64.664 0.154 5.746 322.273 119.069 17.061 5.085 0.038 13.904 7.938 4.266 1.918 21.944 61.203 1.721 2.839 63.231 163.171 58.498 1.912 19.169 213.407 15.380 2205.038 12.527 371.854 12.024 2.227 2.204 0.092 10.926 2.280 9.468 34.216 3.975 0.217 44.952 2.794 86.306 0.648 0.504 37.698 0.874 24.013 1.918 82.690 16.218 13.020 24.354 17.474 42.419 1.024 109.399 59.317 885.099 14.822 6.696 0.258 1.678 59.889 53.549 24.881 0.277 1.193 2.941 6.823 7.354 6.613 21.407 40.723 38.160 129.295 0.846 1.299 27.558 17.688 4.098 0.232 0.103 15.897 335.124 3.700 0.598 22.764 312.467 8.087 0.158 7.538 116.816 287.580 21.999 137.126 31.293 58.032 0.501 2.958 11.368 3.642 0.179 19.459 0.205 0.872 2.426 0.345 8.410 7.594 20.610 155.291 20.955 2.274 67.809 5.418 8.899 0.396 1.723 15.852 0.586 2.791 18.933 102.135 120.530 28.606 19.933 1.505 211.051 5.752 275.228 4.718 44.009 40.149 119.713 2.166 536.196 45.463 253.306 13.857 1.816 137.882 13.828 4.111 135.382 254.831 149.650 45.449 6.994 0.713 1.655 151.215 0.591 130.909 10.503 364615.991 94.699 1.259 15.419 247.497 4.772 3.199 148.829 NA 0.493 NA 6.339 16.441 222.962 16.275 4.468 11.263 6.268 110.266 86.617 20.172 0.395 2.258 45.792 115.123 63.263 6.172 11.775 40.017 55.796 0.451 11.231 3.583 90.161 161.338 9.253 0.863 130.987 111.174 243.496 32.156 8.384 38.637 22.160 115.654 4.065 24.138 1171.453 0.090 2.468 11.449 50.547 42.632 10.410 154.748 179.864 11.959 0.423 0.189 0.151 2.971 188.143 54.729 0.131 420.313 12.891 10.140 23.441 9.676 157.985 250.085 201.502 117.813 70.881 3.282 69.972 21.175 0.187 69.805 4.479 1.114 201.442 18.655 10.303 2.944 37.085 60.262 32.694 149.830 4.914 147.584 11.221 5.177 1.749 18.677 4.386 3.532 0.166 2.798 232.619 39.599 570.207 2.082 7.090 32.973 17.257 0.106 8.695 28.395 MK-0457_Bayesian_5pctCI_high 130.373 363305.734 3.358 160075.363 78.070 1219.993 28001.126 458.243 15.086 360.467 82942.261 6940.992 35.895 200.758 2.115 0.804 0.240 98.258 28.749 29.856 6.132 5753966.494 6.271 105000000000.000 0.740 156968.433 39.985 1614.531 29.032 331.557 10505.981 15.874 700.994 188640.808 16.575 957.092 203.039 76.769 41986.357 1.712 2.106 0.341 2.070 2822123.010 3216485.944 5.576 965595.222 71503.380 13437.438 129845.427 4.091 0.388 2.338 0.387 2490.154 1824.023 14788.424 1565.875 788.632 103621.488 245119.224 5668.048 19.056 12.997 74652.553 94.472 214808.025 0.115 3.685 197.334 4.800 6.283 44.036 1.681 1635.821 6.422 68665.351 0.303 21.533 76626.634 38372.641 730.260 24.427 0.885 342.236 1385.477 15.898 4.279 1453.021 18631.333 7.257 39.370 12470.236 99260.204 63665.621 7.059 1087.786 2538540.836 1801.906 5266332306.000 300.726 216858.425 10213.851 22.410 20.575 0.199 101.048 10.512 90.468 4188.090 44.071 0.322 6463.330 34.233 193242.277 1.882 1.421 6099.731 1.392 1808.585 11.687 34804.432 314.034 980.831 3966.740 497.104 1278.701 3.469 44587.106 11969.296 616519185.400 791.160 35.128 0.611 10.656 14286.924 46013.955 1108.984 0.447 8.104 11.145 199.497 95.612 149.755 1105.773 17224.706 10795.666 813255.006 11.191 3.944 2233.891 459.758 91.551 0.532 0.228 2490.902 5224658.527 27.178 1.582 1922.535 10482313.850 210.587 0.380 127.294 1641958.016 222592.940 1166.776 125354.374 7423.456 30961.507 1.446 5.675 372.412 20.541 0.329 1118.004 0.589 1.373 99.147 0.960 255.903 179.522 1402.624 146063.977 2778.593 6.645 30708.661 86.220 65.079 0.983 5.764 983.778 1.596 9.401 1326.501 187193.852 1670611.024 866.706 13754.207 1.949 1403809.261 41.884 5267676.861 21.270 2431.102 45816.520 123093.561 12.339 555875.707 2434.508 722158.556 718.525 27.126 38112.592 154.903 15.608 45697.552 6011591.018 1166361.929 2356.423 155.136 4.002 16.159 551281.033 3.337 683238.997 1180.626 413000000000000.000 16190.825 17.621 514.760 570518.001 41.792 12.352 33840.040 NA 1.928 NA 81.630 149.530 11268254.570 1369.088 20.198 531.977 18.859 63869.678 43260.705 1095.975 0.764 42.111 14887.839 471040.803 27293.395 30.253 332.986 9926.865 146825.487 0.698 178.234 13.778 30717.875 61525.069 74.836 3.094 41023.486 124629.423 125555.102 790.211 136.278 3029.643 2838.980 1201642.585 24.491 2327.616 711509978.500 0.168 29.192 109.607 9787.878 4315.205 534.697 278034.365 34053.905 508.111 1.078 0.362 0.293 15.663 137585.387 18709.749 0.264 17468328.510 484.734 194.533 1130.935 224.820 45949.581 104057.613 56195.952 139636.794 4564.207 12.372 33116.933 4038.788 0.363 74764.616 25.368 2.700 108369.287 1563.997 315.734 14.831 4421.791 15260.148 3581.726 858549.829 53.909 151055.108 280.003 31.929 6.748 608.624 33.422 10.969 0.350 8.031 150889.038 7144.514 214743.592 4.753 77.177 13086.023 1419.699 0.370 184.657 10923.809 Imatinib_Bayesian_5pctCI_low 15.801 11.890 9.632 11.111 12.152 13.433 7.948 9.086 5.604 0.435 6.653 15.433 6.453 10.790 12.910 11.669 13.857 9.888 9.630 10.259 10.965 11.873 5.447 9.484 12.046 16.190 4.055 10.636 17.605 18.897 11.017 17.181 8.499 14.701 10.253 6.672 12.399 19.098 5.509 6.547 11.699 2.920 11.333 13.310 12.605 4.875 10.317 23.500 10.307 11.156 0.656 5.525 12.675 11.325 15.050 8.143 9.942 3.960 7.822 10.089 5.221 11.127 4.900 9.832 9.457 12.817 8.958 11.900 13.005 10.401 3.223 10.628 9.047 7.774 13.715 10.624 14.283 8.195 9.120 19.435 10.682 13.053 9.630 12.840 12.399 9.922 7.497 14.120 7.338 8.267 7.160 7.578 8.314 13.187 8.699 4.409 3.027 10.215 3.150 14.390 4.536 7.357 8.887 10.136 11.026 5.441 19.315 10.784 11.914 8.348 4.682 15.247 18.701 4.771 6.248 6.428 8.150 12.998 16.524 5.171 16.273 14.531 6.616 3.916 11.371 12.019 12.905 6.258 8.949 9.509 3.051 4.359 15.917 15.126 10.340 9.014 15.543 8.175 8.963 11.856 6.419 8.277 9.933 12.135 9.136 18.601 11.384 10.629 11.535 9.263 4.699 14.036 8.901 13.590 6.066 4.756 13.169 11.240 15.035 12.173 10.901 8.154 13.266 8.754 13.549 10.341 7.951 8.867 4.236 6.238 8.533 5.462 9.547 3.008 7.881 8.998 7.529 5.213 4.791 15.655 11.112 14.606 12.958 8.517 13.992 5.493 8.722 13.594 14.202 6.708 5.215 10.305 4.468 11.246 13.854 11.052 10.807 14.034 5.484 14.598 10.980 3.416 7.076 11.036 20.164 12.613 9.637 11.848 16.991 11.718 7.164 13.360 14.054 12.829 14.424 14.191 13.800 14.414 13.422 16.630 16.374 4.788 11.128 14.698 11.041 12.395 6.231 9.550 7.901 6.727 12.919 8.446 13.118 14.956 15.438 NA 10.153 NA 8.917 10.895 5.492 6.869 6.987 9.708 24.579 11.233 10.886 3.861 10.353 11.297 10.895 13.139 16.310 18.715 4.266 7.497 7.628 8.478 15.028 8.842 9.380 13.273 4.507 8.595 11.686 7.935 12.241 8.586 4.813 5.031 17.549 9.295 5.079 9.062 9.156 3.568 8.138 19.605 18.049 8.419 6.387 6.496 5.800 11.576 14.591 7.648 7.678 9.921 12.333 10.787 8.993 15.738 8.674 13.900 9.967 10.328 12.195 7.445 12.236 10.556 11.406 5.564 9.918 10.359 11.465 13.924 8.211 7.391 9.910 11.506 8.688 8.982 10.671 15.900 9.389 11.101 5.912 10.263 4.754 8.419 11.444 6.550 13.102 8.930 7.131 11.883 9.869 11.053 19.533 13.915 11.067 9.829 11.771 11.006 6.111 8.630 Imatinib_34_IC_50_uM 472.482 403.146 287.321 238.055 309.327 385.253 202.310 204.261 53.415 1.506 102.319 562.392 79.107 331.988 408.013 364.709 416.714 134.491 269.051 289.252 299.077 264.278 43.799 206.211 321.340 432.291 25.847 322.563 470.032 525.316 316.778 499.946 181.835 345.503 294.978 95.478 338.560 434.936 128.291 168.393 324.732 7.897 516.874 345.572 262.907 32.333 272.381 487.651 298.062 274.925 4.950 34.350 405.978 333.686 360.503 170.835 250.560 35.181 87.628 300.155 73.039 185.341 62.646 165.191 196.665 317.825 285.231 368.706 353.577 246.066 16.557 283.638 201.321 195.215 316.176 244.619 386.913 166.368 141.288 557.409 274.157 351.180 218.306 380.087 258.269 291.605 177.133 436.505 125.086 201.019 149.232 207.867 206.645 419.767 164.400 23.896 7.872 406.751 50.785 301.147 48.584 135.870 495.021 307.108 254.017 135.179 516.255 246.929 272.626 157.370 76.051 441.554 495.566 143.151 242.306 97.485 183.571 355.349 393.507 66.666 458.885 396.074 68.190 57.289 304.174 264.145 425.387 82.657 179.720 321.115 29.722 62.521 435.502 319.130 305.852 200.177 527.000 170.051 193.601 393.075 107.641 204.343 238.674 385.870 225.811 524.476 322.402 290.383 317.158 153.285 32.089 354.249 253.611 341.928 67.249 107.792 322.467 279.947 327.078 265.204 297.704 201.805 369.075 277.827 398.497 292.013 179.756 234.065 80.391 265.337 168.663 30.874 260.265 11.733 162.764 213.023 199.657 79.107 89.613 522.905 302.596 384.675 385.176 185.119 389.436 52.353 171.898 427.477 386.488 123.051 103.762 236.299 40.358 218.045 403.146 254.118 276.497 389.008 708.748 320.313 315.292 15.635 108.701 308.000 496.210 333.986 327.832 376.267 455.684 440.187 121.146 372.971 376.757 377.473 394.453 426.836 383.331 432.508 339.441 394.887 524.738 49.151 332.520 453.774 245.476 417.673 146.922 226.875 176.038 160.549 365.585 207.390 386.179 428.418 358.956 NA 324.992 NA 187.129 298.987 101.332 136.061 81.810 260.473 534.697 326.817 333.519 46.247 302.294 322.467 365.257 307.631 442.615 527.738 21.206 162.959 201.865 142.394 351.848 201.603 287.177 371.073 21.306 209.307 297.080 242.403 395.006 145.358 31.056 33.757 625.593 272.762 34.179 238.818 171.246 65.516 204.180 726.472 514.091 260.265 150.807 125.061 108.462 314.946 422.378 330.994 201.301 260.395 372.896 245.353 241.797 435.459 217.196 439.923 235.262 243.715 352.095 175.125 389.553 310.040 275.476 50.039 318.429 368.964 369.481 391.623 231.181 136.770 274.898 322.080 197.710 221.584 222.027 342.921 216.307 305.913 55.429 272.626 48.096 220.854 257.804 86.099 315.829 266.320 155.571 314.536 282.111 284.149 454.592 334.655 329.178 271.782 362.854 337.309 74.881 215.035 Imatinib_Bayesian_5pctCI_high 116973.185 261267.483 218076.239 61432.851 105219.087 284560.169 248848.610 88760.765 10819.442 8.228 21657.346 497275.760 12470.236 110348.630 462823.014 242001.693 223887.730 33262.969 1033539.627 162462.096 142642.959 65205.559 5295.962 120499.394 123204.395 147694.318 2831.891 258125.196 153322.680 182499.005 92272.368 247409.466 352392.186 59474.326 673134.204 40647.800 62292.730 55575.626 426983.223 838022.308 205869.963 76.692 114685023.200 127121.678 52239.803 2226.754 101854.439 40428.894 153108.179 71125.415 213.727 2429.401 261790.541 129159.067 57630.084 71668.027 259730.543 14478.209 9360.931 119479.490 23980.589 28684.150 23818.074 19101.077 35799.886 89223.523 137571.629 208126.220 96790.100 101184.413 917.177 105461.370 74824.451 222148.199 51875.402 52733.173 100037.461 57313.988 32958.353 197857.034 330810.175 132230.250 63805.840 104047.208 70544.571 70954.918 189226.502 137406.642 60609.080 95130.033 59647.052 133719.553 186577.130 159915.367 103631.851 1388.529 57.375 3816330.817 27728.055 42188.376 14965.458 27664.354 19925283.280 196594.793 51503.240 211546.476 80033.454 235460.865 50883.806 44267.232 65225.123 85665.033 125592.774 1088052.545 218994.085 47268.529 159468.231 167694.642 102857.519 20975.283 237233.460 196241.241 12155.050 45224.760 117265.984 47443.746 896810.627 24936.802 23346.445 191606.678 4587.085 46550.825 142357.959 59142.200 115925.150 62724.036 261136.882 45021.706 171647.803 171493.390 72867.646 58465.961 96674.022 313075.608 66476.249 182955.823 181026.734 118018.893 119109.677 15120.398 2494.641 137929.781 108662.280 267292.809 13058.571 135849.101 78018.402 76183.486 52738.446 54170.946 177797.404 425874.508 90391.001 419869.824 170672.194 413205.365 91399.931 111781.349 37801.346 6077475.780 45184.076 1001.446 90291.626 338.187 98429.910 87535.526 107398.340 54030.285 82967.148 269871.177 202541.483 135957.824 150979.599 179997.817 136352.674 14174.502 91308.577 167393.064 175360.652 109032.360 162982.808 39517.544 8459.962 42251.706 148375.277 71746.905 65127.359 131294.740 425127635.200 42066.206 104610.583 354.143 23647.200 180268.016 84567.051 122982.826 213224.312 105947.609 177690.757 1852784.128 51720.009 109338.079 138441.066 120198.521 154260.807 206426.563 87877.581 161377.239 154322.524 170962.583 176151.553 9727.381 159484.178 161538.697 47743.585 180773.474 94693.439 106064.216 99389.326 98410.226 103228.474 143300.629 234966.916 178349.431 66449.663 NA 130092.368 NA 104015.999 199725.659 336482.022 58384.166 16744.079 132124.508 77358.056 217945.432 183523.866 44103.746 106159.717 112949.941 283792.893 76879.920 311888.178 151645.373 1029.574 28793.358 69529.055 39711.655 146737.419 146796.125 144798.732 117995.292 564.251 69452.615 78158.962 286616.396 2071534.096 151236.483 1469.827 2760.867 766047.916 110062.097 2704.034 116180.466 46812.241 166808.212 582334.323 317711.812 296588.223 667103.176 74779.570 47434.259 195223.435 174486.037 160395.834 5917354.311 132614.274 103321.421 113788.871 73328.161 101154.062 150046.421 90174.323 122369.447 99220.507 91180.834 118136.971 62050.261 242292.269 144987.093 166741.502 6247.271 210912.788 388675.467 256478.469 194308.037 78770.985 34002.863 114450.764 98824.418 48620.474 48615.612 108966.960 59724.643 58407.524 379079.036 4979.576 56229.679 11143.370 75940.089 43221.788 18222.275 93910.737 1419620.301 123586.921 148925.283 82355.457 112904.770 108120.324 65630.775 108477.711 277340.147 110161.197 134928.461 17101.133 176028.290 TAE684_Bayesian_5pctCI_low 0.899 1.661 0.477 4.887 1.139 2.853 1.230 1.087 0.501 0.352 9.889 2.168 2.164 1.618 0.461 0.685 0.621 1.042 2.151 0.375 1.298 1.432 0.486 3.854 0.475 1.076 0.302 0.812 1.232 1.105 0.914 1.413 1.061 1.769 1.596 2.230 0.791 0.164 3.889 0.354 0.706 0.073 0.605 1.861 5.348 0.267 3.061 4.023 4.328 1.713 0.258 0.329 0.400 0.284 2.347 9.579 1.283 1.085 3.666 1.909 1.215 0.823 0.590 0.629 0.411 0.854 6.171 0.409 0.838 0.716 0.301 0.576 1.098 0.203 0.454 0.640 1.742 0.430 0.662 8.099 1.058 1.404 0.289 0.352 0.503 1.163 1.373 1.094 2.076 1.618 0.416 0.530 1.002 2.071 0.003 0.681 0.560 0.870 3.182 2.465 0.746 12.165 0.520 0.687 1.357 0.417 1.299 0.832 1.240 5.107 0.164 0.462 2.035 0.401 1.297 0.535 0.371 1.457 1.978 0.256 0.418 2.674 1.573 0.326 1.347 1.498 2.624 0.668 0.538 0.643 3.582 0.294 0.881 0.910 1.292 6.239 4.446 1.200 0.412 0.966 0.367 1.198 2.207 1.731 1.662 0.635 1.300 1.016 1.123 1.035 0.525 2.277 0.338 0.758 0.462 2.437 11.387 1.371 0.382 0.865 0.574 0.478 0.249 1.120 2.975 9.987 0.477 11.254 2.770 2.246 0.607 0.859 6.744 2.269 0.690 1.173 0.595 0.540 0.239 0.496 3.312 0.879 1.552 5.462 1.535 0.674 1.122 0.764 2.088 0.181 0.253 3.895 0.345 0.921 1.781 0.868 1.985 2.447 0.287 1.940 2.498 1.313 1.594 0.922 1.443 0.390 1.509 1.047 16.226 1.009 3.214 1.128 0.910 3.917 0.027 1.674 4.206 1.252 1.437 1.872 0.207 0.137 0.973 1.058 0.808 1.992 1.443 3.951 3.804 0.156 3.758 0.956 2.432 0.251 2.542 NA 0.760 NA 1.360 2.013 0.239 5.451 1.088 1.328 3.235 0.943 1.823 3.874 0.273 0.882 0.812 2.418 0.340 1.174 1.482 3.295 3.790 0.250 1.939 1.594 1.743 1.663 1.511 0.137 11.860 2.517 2.955 3.017 0.447 0.458 1.170 4.529 0.623 4.697 0.954 0.037 0.210 3.299 0.835 2.638 1.640 3.573 14.627 2.023 0.504 0.331 0.209 0.942 1.662 0.395 0.524 0.324 0.500 0.608 0.670 0.565 4.995 6.107 3.112 5.690 2.124 0.951 2.518 1.661 0.307 0.865 0.825 0.361 2.358 1.192 1.436 0.247 2.295 2.863 6.432 0.529 0.556 1.016 0.727 0.619 1.048 1.942 0.377 0.655 0.609 1.939 6.477 1.614 3.051 0.831 0.656 1.734 1.163 0.479 1.363 4.534 TAE684_35_IC_50_uM 1.518 2.656 0.849 39.929 1.754 11.667 2.578 1.678 0.720 0.581 259.745 4.476 4.344 2.863 0.667 1.244 0.932 1.398 4.137 0.695 2.450 3.468 0.689 17.784 0.696 1.613 0.491 1.391 1.745 1.510 3.077 2.008 1.578 2.995 3.361 4.385 1.341 0.222 46.782 0.559 1.120 0.106 0.844 4.272 41.550 0.367 19.854 12.999 45.600 3.813 1.037 0.422 0.555 0.552 5.585 237.152 2.608 3.004 15.574 10.009 2.439 1.075 1.118 0.859 0.666 1.628 177.346 0.612 1.302 1.133 0.450 1.361 1.882 0.305 0.744 1.130 3.592 0.657 0.898 306.617 2.034 2.448 0.426 0.634 0.802 4.890 1.949 1.359 4.618 3.171 0.712 1.085 2.043 9.019 0.019 0.941 0.858 1.455 51.080 6.321 1.417 311.843 1.591 1.183 2.235 0.626 1.718 1.164 1.641 54.250 0.277 0.673 3.808 0.882 18.726 0.805 0.567 2.274 2.543 0.519 0.655 8.165 2.232 0.881 3.272 2.602 5.032 0.946 0.897 1.554 165.869 0.483 1.167 1.329 2.844 108.940 32.182 1.849 0.568 1.756 0.524 3.230 4.999 2.679 2.876 0.896 2.211 1.606 2.059 1.318 0.755 4.584 0.677 1.010 0.651 21.497 245.133 1.874 0.542 1.339 0.947 0.921 0.400 3.410 19.759 1017.089 0.856 366.611 18.458 12.128 0.914 1.154 148.651 7.817 0.970 1.789 0.983 0.928 0.545 0.784 21.143 1.318 2.690 57.576 2.902 0.944 1.930 1.175 3.232 0.278 0.588 33.482 0.534 1.408 2.877 1.772 7.616 7.082 0.658 2.826 7.321 2.042 2.902 1.708 2.021 0.703 9.689 1.610 415.383 1.534 41.809 1.834 1.538 19.588 0.060 4.180 47.622 2.383 2.364 2.736 0.274 0.270 1.666 1.762 1.216 6.176 4.267 18.013 23.944 0.310 25.521 1.630 7.613 0.417 4.380 NA 2.050 NA 2.858 2.823 0.346 62.602 1.681 4.141 6.074 1.786 3.878 49.954 0.457 1.580 2.656 10.401 0.423 1.424 2.579 32.259 57.128 0.329 2.558 2.278 7.844 2.555 2.511 0.254 409.526 26.201 10.234 6.203 0.660 0.778 2.051 77.711 0.964 52.107 1.625 0.063 0.340 6.754 1.197 7.338 4.211 45.782 401.858 5.752 0.790 0.514 0.416 1.472 3.522 0.627 0.806 0.419 0.781 0.934 1.086 0.964 97.984 136.006 19.252 95.995 2.743 1.341 14.426 10.991 0.480 1.413 1.527 0.579 14.981 2.424 10.458 0.350 4.456 6.563 124.898 0.981 0.800 3.125 1.438 1.176 2.034 5.245 0.534 0.952 1.005 3.050 191.234 2.913 5.795 1.110 1.367 4.876 1.906 1.012 2.125 47.957 TAE684_Bayesian_5pctCI_high 2.666 5.423 1.377 5575.850 2.922 296.130 10.225 2.795 1.026 0.952 158657.013 23.936 15.005 7.539 0.965 2.303 1.325 1.879 13.827 1.171 6.424 17.754 0.964 494.230 1.007 2.453 0.784 2.362 2.622 2.062 35.248 3.194 2.530 7.311 11.141 15.126 2.237 0.292 11760.480 0.851 1.672 0.145 1.132 29.297 5528.656 0.484 1539.326 185.304 8474.356 20.820 6.359 0.557 0.769 0.993 31.159 114875.016 7.664 15.258 256.929 552.526 7.934 1.376 2.079 1.162 1.077 3.553 57497.687 0.910 1.929 1.706 0.689 4.341 3.657 0.466 1.157 1.891 16.680 1.017 1.203 2941999.470 4.988 6.082 0.624 1.075 1.181 107.889 3.090 1.623 20.023 10.712 1.177 2.325 5.638 284.604 0.078 1.247 1.260 2.626 21514.879 55.584 3.221 126715.539 7.798 2.035 5.235 0.918 2.274 1.637 2.197 8964.252 0.444 0.945 11.345 1.819 8254.386 1.152 0.872 4.197 3.963 1.052 1.015 117.132 3.614 2.719 18.502 6.721 15.674 1.304 1.541 5.465 1344187.098 0.799 1.499 1.812 12.653 74764.616 3053.977 3.118 0.802 3.979 0.761 27.522 22.617 6.082 8.566 1.213 4.919 2.539 5.464 1.611 1.067 20.843 1.273 1.330 0.896 4832.407 127784.432 2.732 0.771 2.005 1.448 1.753 0.624 23.715 2250.933 82747139.200 1.535 309619.685 1041.170 628.415 1.301 1.502 69230.722 119.761 1.305 3.083 1.513 1.619 1.063 1.183 1901.884 1.929 6.318 15490.776 9.961 1.273 3.966 1.671 7.305 0.431 1.357 6445.903 0.804 2.142 6.398 4.772 212.874 127.269 1.519 5.173 85.773 3.646 8.147 4.026 2.975 1.215 761.888 2.500 101407.264 2.480 19576.791 3.359 2.881 822.378 0.116 21.656 45242.853 6.689 4.662 4.849 0.354 0.506 3.217 3.348 1.798 84.970 47.153 556.852 2045.096 0.604 3221.492 3.037 99.375 0.673 13.131 NA 11.300 NA 10.043 5.141 0.520 10899.803 2.798 77.610 23.634 3.843 19.387 31501.801 0.738 3.089 18.967 397.741 0.543 1.662 5.789 7269.916 20559.944 0.450 3.719 3.931 428.590 5.170 5.122 0.449 215539.615 14699.959 113.250 27.542 0.980 1.371 4.329 30871.849 1.437 36684.148 3.119 0.101 0.535 29.889 1.682 71.065 52.342 25187.421 118302.478 96.989 1.180 0.816 0.906 2.340 15.155 0.944 1.187 0.544 1.164 1.338 1.591 1.566 39147.819 64582.580 1455.930 61132.566 3.976 1.814 967.679 1233.610 0.735 2.374 3.377 0.917 908.777 7.104 814.277 0.508 16.381 37.792 69410.956 1.823 1.130 32.047 3.094 2.437 5.667 40.601 0.777 1.344 1.511 6.828 77342.586 7.862 19.645 1.423 3.330 52.003 3.534 2.124 3.899 15051.004 PD173074_Bayesian_5pctCI_low 14.238 7.911 5.208 6.566 4.257 12.512 6.415 10.760 1.010 0.756 14.832 4.677 7.818 4.871 7.988 9.052 15.114 12.279 6.193 8.848 4.183 6.518 13.172 3.509 9.887 4.287 10.164 5.540 6.052 15.665 9.840 9.967 8.845 10.626 11.304 5.403 1.224 6.244 13.419 6.025 7.600 1.537 5.249 4.151 15.325 0.838 6.932 19.227 12.348 7.071 3.396 7.151 15.258 10.036 10.138 9.961 11.765 6.579 7.935 10.660 10.021 13.063 4.234 8.023 6.046 8.183 8.731 9.128 9.247 12.840 5.644 4.262 6.796 6.188 8.354 7.457 10.888 8.462 10.297 12.049 7.154 11.923 9.042 2.464 3.248 2.289 13.101 8.087 10.080 2.764 1.248 4.732 9.104 14.893 1.639 6.775 4.133 5.530 0.300 13.238 3.977 13.756 4.869 2.049 12.094 6.839 15.983 7.396 3.644 5.464 2.162 3.671 11.354 7.304 5.920 9.289 5.048 12.229 16.514 2.771 12.608 13.706 9.289 10.542 5.945 10.169 4.932 6.347 11.522 1.279 9.189 3.893 10.993 13.850 9.108 6.341 6.479 3.782 7.996 0.400 6.725 8.496 8.057 12.263 9.780 12.876 9.683 12.796 10.316 9.743 2.508 11.876 1.804 11.587 1.998 6.693 9.020 14.421 1.656 3.402 7.305 7.486 7.487 5.415 8.764 8.528 5.972 10.090 5.141 1.086 10.469 5.702 7.778 7.063 5.270 1.515 1.250 0.582 4.354 15.499 8.565 13.527 6.782 11.736 9.565 5.123 10.253 0.483 7.198 4.514 0.757 10.451 1.955 5.511 12.789 8.071 9.529 10.571 2.938 18.105 13.666 6.874 6.382 8.868 1.757 5.787 7.002 12.129 15.215 11.195 4.420 5.893 6.076 13.035 12.357 8.045 8.445 7.655 9.603 6.224 11.134 4.166 8.836 7.310 9.936 3.023 10.018 13.787 8.130 8.548 10.848 9.047 9.435 0.464 9.104 NA 2.132 NA 8.268 10.182 2.350 3.498 3.192 9.530 17.245 7.142 12.138 6.320 6.645 12.925 7.329 9.230 9.929 17.380 10.975 9.882 11.825 4.585 10.757 11.673 2.292 5.968 10.818 0.852 10.916 7.133 11.769 14.076 3.906 4.392 12.742 2.829 5.919 8.253 8.000 1.427 6.971 15.041 4.161 12.857 11.835 8.601 17.956 4.649 9.968 4.516 8.079 4.934 10.573 3.497 6.905 13.824 5.154 11.754 1.944 5.666 10.282 5.204 8.138 12.570 11.368 9.271 5.884 9.493 10.607 5.959 4.899 1.483 9.066 7.564 9.234 10.008 5.148 13.527 8.678 8.244 3.077 5.181 5.352 15.356 3.881 8.962 4.831 3.768 1.053 10.989 6.950 11.407 12.136 10.592 5.593 14.019 11.817 10.213 3.589 9.248 PD173074_36_IC_50_uM 337.275 516.978 106.453 108.224 36.756 262.959 141.599 273.144 1.595 1.480 398.617 48.604 152.994 49.491 321.019 214.627 432.681 360.251 60.971 259.200 30.292 121.742 395.876 33.791 228.903 34.039 218.459 66.016 63.612 383.255 278.662 208.054 164.696 399.135 256.211 36.716 3.474 53.410 502.402 319.641 131.683 2.331 47.181 48.115 418.175 1.115 134.666 430.997 338.187 171.366 100.083 253.003 361.695 271.700 187.635 243.813 352.729 106.698 1380.223 324.764 216.351 382.489 36.489 122.830 85.447 441.113 347.339 245.943 280.900 390.294 80.761 114.457 105.879 80.915 255.699 208.930 271.456 207.286 202.573 612.593 92.241 324.018 167.603 25.920 14.265 27.295 400.014 86.574 229.087 10.111 4.279 128.291 203.507 517.857 3.172 87.549 21.039 81.142 16.322 439.000 22.461 391.114 696.731 139.240 592.588 155.835 523.062 531.286 12.457 76.348 7.958 14.356 270.778 234.393 196.134 238.126 59.412 334.053 535.285 12.811 315.198 378.191 191.368 379.707 126.964 242.427 17.925 73.237 267.254 7.072 204.977 40.290 269.724 326.817 269.940 85.627 97.935 18.198 282.393 1.541 109.717 273.500 179.558 503.609 638.550 526.736 974.671 361.297 288.992 234.206 6.439 3488.754 40.049 837.817 5.778 158.143 223.006 353.647 3.008 14.960 159.365 679.257 158.080 185.843 294.271 235.922 62.684 233.201 109.071 2.071 258.708 51.604 195.390 144.460 38.004 4.475 2.324 1.051 131.815 466.800 261.439 544.899 169.389 3487.708 240.063 54.850 814.277 1.245 84.192 35.030 58.195 276.635 3.765 74.151 469.468 341.894 237.864 441.907 69.958 522.748 454.274 148.755 115.469 922.881 3.823 111.208 236.631 272.489 456.460 1286.010 25.101 129.257 127.587 377.134 358.203 157.402 219.291 159.876 213.642 48.970 308.092 35.446 261.517 150.928 294.182 90.044 282.421 379.100 158.698 257.186 290.993 248.514 219.774 1.195 154.841 NA 52.636 NA 190.681 244.130 6.460 20.395 9.324 247.918 412.815 326.654 333.786 233.808 171.606 404.843 314.725 197.019 555.406 406.913 245.108 298.987 406.141 20.310 155.726 229.775 16.550 82.187 248.887 4.864 273.035 188.670 231.458 356.773 14.938 20.180 395.796 20.668 57.668 184.768 1709.575 17.404 115.596 353.082 20.027 349.918 324.797 233.738 537.538 46.307 250.886 80.988 141.996 100.263 294.712 11.879 137.593 298.867 71.186 301.901 3.396 84.302 309.296 101.799 194.202 348.069 269.859 199.059 140.485 269.158 263.170 88.606 75.671 3.020 228.241 157.024 269.724 209.579 40.723 330.663 212.789 203.976 8.947 162.992 67.215 428.890 35.389 170.613 38.579 13.783 2.734 220.611 183.516 281.519 235.003 231.366 77.177 396.113 329.244 286.117 18.149 322.144 PD173074_Bayesian_5pctCI_high 89608.011 66240326.690 42714.768 25210.100 8694.970 61920.092 230659.990 173841.632 2.738 3.251 94230.577 23887.247 27307.045 18556.956 5438968.571 60276.645 159563.940 385039.036 8390.874 87029.289 4185.578 27067.797 231630.799 2930.710 75993.265 4792.943 77800.256 10728.940 17140.511 116587.810 124666.818 97938.989 92263.141 7267333.493 106617.186 2566.504 29.102 9572.982 425278.701 22075964.600 47126.936 4.422 13188.493 27375.398 171013.880 1.481 37410.250 100167.594 95368.155 216187.205 623248.129 6754368.239 45807.357 73474.964 57872.639 41506.279 586659.581 18640.651 1748982452.000 95520.867 62586.195 769810.762 4919.686 20731.302 24149.042 12026222.120 400032.071 72707.513 202157.020 140575.501 20390.003 537992.555 172094.668 20545.557 176928.328 203170.336 104349.383 157534.538 42548.505 52158619.050 18805.412 81903.745 62950.249 5277.459 535.071 7331.240 136475.447 13118.779 138095.396 321.533 33.957 243555.470 52328.687 726722.516 10.043 16322.503 636.510 40263.475 26076.766 157581.805 1002.748 125693.289 1488597145.000 361566.045 4969848.924 166991.802 723676.682 60575434.650 256.236 27184.439 149.426 345.399 110536.383 823731.577 106393.525 84770.256 22606.664 272747.026 188188.613 476.992 57245.253 109864.163 53257.824 785911.917 84128.444 64627.804 159.876 22198.944 91867.261 482.364 67050.410 7891.172 67057.115 52775.376 159452.285 45256.428 41303.396 611.307 3221958.621 11.792 80306.031 379534.204 59898.096 10573907.840 117623570.200 5019796.736 2751466832.000 139469.330 139246.358 79809.674 78.587 265000000000.000 57549.458 232128115.700 52.699 102364.986 444719.934 102785.544 7.121 625.530 61114.229 225650973.900 55960.424 784027.990 1327091.150 2682876.238 7365.042 53760.808 25721.950 5.074 64042.359 8515.131 171236.342 63882.453 3989.814 34.981 6.053 2.043 892337.765 328897.029 442811.743 2869361.244 461944.485 1080000000000.000 100679.753 53992.477 63306590.690 4.664 16422.375 4783.367 444630.998 88318.069 12.594 33426.357 1281830.894 6428167.093 82215.572 3595163.400 142059.321 141647.945 212840.854 302700.758 215906.344 2092237700.000 13.015 165777.201 137847.048 43813.620 156686.144 189216042.100 1660.709 504034.502 167259.203 109546.019 283027.685 55475.680 148330.771 52770.099 102857.519 3199.341 536649.253 11284.665 326668.116 57033.837 471323.512 521883.677 129988.336 153983.387 97567.527 283821.273 101123.720 260954.150 99837.586 4.337 29175.949 NA 46574.106 NA 72911.379 224852.520 59.686 1412.759 79.297 64292.612 66363.335 5650191.521 96925.701 7398590.004 65689.870 216685.008 2481068.817 55497.874 8449349.381 55592.301 31135.378 101813.705 226862.639 540.179 36062.182 46471.756 2151.241 16672.234 73445.580 139.645 98548.097 149492.275 67649.822 331273.633 359.783 824.684 520372.406 2790.009 15626.133 116389.779 10412782761.000 8750.796 49148.421 82174.474 1078.256 130300.682 141832.207 102836.950 175887.524 6593.239 613969.174 63006.930 36787.007 218950.291 125844.211 189.048 34710.586 118539.320 32422.244 83692.111 10.956 83416.382 142201.451 62075.086 65637.339 116157.232 296855.272 70136.597 64003.945 88220.973 93704.360 22345.942 29372.085 10.020 100972.149 111814.888 135740.466 37597.769 3717.847 68816.581 108098.702 186372.008 119.893 167728.185 24194.969 121491.551 5126.611 55982.812 5801.084 276.083 12.169 36058.576 47372.634 78057.421 110691.242 171321.982 24190.131 122626.693 95922.898 97314.181 1726.929 5599008.016 PF-2341066_Bayesian_5pctCI_low 4.296 4.598 3.330 1.638 2.794 3.574 3.816 1.598 3.544 3.862 5.331 5.227 2.983 1.902 2.679 4.456 8.910 8.587 3.090 1.986 3.746 1.502 2.509 1.950 2.643 4.215 2.843 1.602 5.982 20.219 1.966 3.399 5.289 2.271 3.913 2.820 6.152 3.809 7.943 3.578 4.858 0.903 2.123 3.317 4.015 1.872 4.572 16.227 1.895 1.530 1.089 9.532 1.805 5.438 3.338 6.969 2.726 3.717 2.902 8.404 3.428 4.272 2.218 3.295 3.114 2.786 5.044 1.979 2.100 9.511 1.811 1.225 3.462 2.372 4.307 0.828 7.620 0.562 5.012 18.670 3.981 3.890 2.178 2.472 6.706 1.587 4.633 7.237 3.040 4.234 1.718 2.831 3.482 5.329 9.058 1.518 1.866 3.007 2.527 6.626 1.819 5.386 1.074 4.824 1.288 12.746 7.984 3.886 3.693 9.095 1.031 4.492 3.945 1.188 3.383 1.935 0.906 3.495 8.838 2.654 3.251 8.217 3.169 3.078 2.314 3.763 5.760 3.839 7.152 7.069 7.880 0.720 8.580 4.267 1.834 3.722 1.211 2.764 3.449 1.302 3.835 0.523 2.435 2.167 2.851 1.865 1.150 3.434 6.009 5.833 1.927 2.849 1.325 4.265 3.196 4.022 14.910 2.568 1.979 0.502 12.025 4.489 2.083 2.222 2.219 3.139 1.556 5.152 2.994 4.551 6.782 4.239 4.605 1.401 1.241 4.245 1.649 1.635 0.017 1.420 3.359 2.645 2.684 0.096 3.924 5.707 0.610 3.882 2.199 1.477 1.864 2.625 2.460 1.734 3.309 1.639 2.682 2.659 0.332 7.491 7.949 2.566 2.127 2.354 4.325 2.355 0.225 3.088 8.948 3.032 7.164 3.559 0.816 3.898 1.025 2.887 3.027 1.633 2.805 2.496 2.468 1.603 0.682 2.951 3.889 5.297 6.765 5.510 9.319 1.640 5.459 5.316 2.501 0.267 8.833 NA 6.752 NA 2.335 7.060 2.914 2.705 3.094 3.159 2.673 6.556 1.282 2.060 0.945 3.276 1.490 2.843 2.829 6.090 2.840 4.287 4.674 2.444 4.237 4.152 2.700 3.482 2.197 2.281 4.871 5.220 3.883 2.697 3.619 3.099 1.842 1.008 3.843 9.123 2.395 0.174 0.802 12.213 1.793 3.889 2.849 3.720 5.682 2.258 2.456 0.792 2.555 2.839 5.127 2.681 1.989 3.783 5.059 5.605 3.297 1.160 5.369 3.496 5.857 3.808 4.000 5.233 1.489 3.484 0.683 4.392 1.511 2.817 4.737 2.563 3.770 1.971 3.569 2.919 1.520 6.690 2.927 1.106 3.305 5.250 2.374 1.874 4.558 1.637 1.869 4.505 1.705 2.341 5.568 6.163 1.097 9.309 3.124 2.435 1.569 2.625 PF-2341066_37_IC_50_uM 30.517 56.379 36.672 2.439 8.471 15.421 20.872 2.409 16.587 47.314 46.979 52.510 10.404 3.772 12.223 63.269 246.411 183.369 6.734 7.957 22.065 3.962 6.656 5.963 5.670 31.497 6.097 3.532 87.847 528.002 7.236 12.023 39.627 5.041 18.094 6.389 141.203 12.018 230.973 43.869 66.281 1.333 2.932 21.426 17.238 2.353 78.163 341.074 9.966 2.427 4.412 208.096 2.598 133.246 8.889 139.115 11.566 27.396 7.252 215.164 18.031 13.941 8.048 10.254 11.431 18.625 175.107 4.383 6.739 241.483 4.190 5.766 10.531 5.086 51.014 1.884 182.217 1.641 29.353 547.028 24.030 26.435 4.145 8.200 122.768 9.273 55.268 61.461 8.493 55.440 3.488 35.531 17.777 99.494 168.006 2.102 4.433 8.197 33.242 148.487 6.448 79.297 11.291 83.080 2.921 334.053 149.068 29.752 15.173 214.005 2.083 31.862 18.192 5.642 99.614 3.617 1.574 12.078 155.493 8.327 18.901 157.402 7.687 30.232 9.891 20.993 40.707 25.051 129.814 221.406 158.968 2.022 145.868 31.224 5.611 18.145 1.795 9.237 10.734 3.759 21.067 1.480 6.581 7.961 11.544 4.560 3.457 17.957 154.748 80.511 4.626 13.954 6.095 14.095 16.603 75.271 374.728 5.991 3.038 0.847 352.870 456.094 4.208 7.877 7.179 13.354 3.172 103.596 45.047 70.464 158.428 14.773 60.310 2.873 1.738 57.380 4.070 3.727 0.064 2.971 16.188 9.017 6.941 0.191 28.310 55.986 0.918 31.010 3.345 2.564 6.795 13.499 6.327 3.128 15.185 2.406 20.536 10.124 7.627 101.220 194.280 8.598 4.566 9.897 18.887 8.905 1.603 20.538 1216.946 17.128 171.743 27.705 1.976 39.690 2.676 11.408 18.191 3.159 8.388 3.826 3.636 4.554 1.728 8.658 25.368 114.595 183.149 80.054 458.427 3.297 71.873 62.004 6.363 0.689 149.172 NA 188.708 NA 7.220 68.525 11.926 11.022 8.111 49.004 7.982 145.402 2.425 10.495 2.712 18.122 5.797 11.393 5.817 42.996 6.816 58.627 104.564 4.214 10.499 21.676 24.737 15.640 3.573 8.626 72.125 86.220 18.460 4.728 14.838 6.781 3.303 2.597 12.262 402.462 12.964 0.357 1.551 379.745 2.618 16.961 18.240 49.521 69.951 11.256 16.058 2.128 7.429 11.996 76.708 6.314 4.015 9.418 61.905 93.363 12.988 2.036 97.798 30.072 116.769 42.001 9.153 68.074 6.395 92.805 1.011 68.752 3.032 8.986 98.485 5.667 79.966 4.928 14.266 6.439 6.600 151.366 7.753 24.981 11.574 59.716 6.384 3.384 25.411 2.782 3.994 23.007 7.916 6.190 24.398 59.740 1.739 273.718 13.934 11.968 2.664 15.936 PF-2341066_Bayesian_5pctCI_high 2614.949 48693.460 8768.316 4.892 123.742 653.603 1190.466 4.585 566.626 20034.278 4384.365 7977.657 258.656 15.185 567.590 16848.215 324292.122 1047168.068 36.518 196.507 2438.163 31.206 73.781 52.379 30.744 4902.988 28.706 19.706 104537.381 127197.974 199.477 171.709 4822.270 31.218 554.408 36.620 69682.187 179.810 103704.418 37101.030 91546.288 1.869 4.911 2235.231 449.979 3.309 33782.561 45661.008 600.643 4.861 71.722 197758.131 4.773 63780.323 66.129 40219.209 658.984 3801.686 49.581 57953.718 1568.225 165.025 256.390 104.366 290.528 1200.748 174975.283 31.693 123.643 60542.447 21.279 155.804 92.963 23.176 26045.493 5.662 177193.919 7.872 1621.002 193842.257 1357.093 2445.244 18.064 140.865 31232.047 1605.997 11678.444 7611.382 91.159 47992.499 14.610 15707.601 850.139 42104.083 44139.043 3.259 33.218 80.842 9607.507 256632.403 122.193 46485.699 2426.002 23008.063 13.719 92744.159 131913.278 3917.073 468.811 66482.897 6.315 4695.219 1418.138 135.829 126033.119 13.818 3.111 261.700 34523.654 195.156 2406.431 44320.385 43.917 9865.509 443.634 1343.724 6660.834 2481.454 76511.780 139846.406 62655.077 9.405 19910.450 3467.538 66.640 830.228 2.911 235.898 165.621 43.624 947.380 6.030 71.136 120.856 408.626 34.063 26.031 915.710 74809.488 70572.794 29.746 717.017 188.406 148.963 663.945 38108.781 121759.127 42.449 6.462 1.433 114588.187 22818906.890 17.999 157.433 164.432 506.083 11.616 53369.783 13496.693 56607.683 111781.349 210.103 35678.374 10.304 2.561 13560.277 31.150 17.784 0.218 14.178 737.599 207.950 60.340 0.400 4828.543 27487.867 1.381 6365.831 7.738 7.119 133.193 824.519 45.205 8.214 466.846 4.350 2322.733 219.598 3124.095 16511.295 100317.958 126.242 21.600 308.648 536.947 268.325 40.318 2087.036 1177076902.000 729.165 683854.189 3072.356 7.340 8787.627 12.283 376.380 1470.121 10.360 128.265 8.912 7.487 39.801 6.380 99.415 2546.309 255735.759 93106.567 50883.806 9793211.505 16.489 13236.057 38975.947 70.133 1.959 25770.868 NA 86751.241 NA 114.000 7677.122 258.967 511.834 55.696 18884.561 39.793 174311.638 7.250 366.427 21.228 752.800 110.311 390.645 24.162 2761.143 54.582 32070.760 148197.334 11.245 57.026 822.131 5615.579 809.567 9.152 225.135 23512.795 19856.764 514.091 14.180 500.146 32.220 8.974 13.581 187.335 5466231.515 830.145 0.706 3.527 54830.397 4.756 487.992 2492.147 18715.363 24379.551 678.171 1149.290 9.794 90.577 520.505 18506.920 46.150 17.128 54.598 9618.081 85391.343 475.563 4.806 45492.375 5585.337 38124.027 11502.274 39.413 18104.214 166.751 49330.607 1.398 73276.849 13.619 113.829 269979.147 32.256 146590.755 36.741 399.215 38.141 285.945 357074.599 67.451 34874.110 184.270 7684.803 65.977 11.362 942.560 6.901 25.465 773.016 517.133 65.053 574.730 6878.803 3.001 72373.826 462.294 767.470 6.635 2314.618 AZD0530_Bayesian_5pctCI_low 7.949 1.892 1.166 3.235 4.704 1.097 1.890 10.988 2.594 2.465 17.745 10.514 4.019 4.366 6.319 2.036 10.086 17.547 2.288 1.250 2.362 2.118 3.047 6.537 2.946 2.362 7.525 1.670 2.178 10.077 4.848 0.204 3.320 12.966 3.741 4.883 4.245 1.050 0.601 1.856 0.297 0.017 3.786 1.128 4.762 0.328 2.904 12.554 10.161 6.774 5.085 1.417 0.086 10.851 6.001 13.352 1.838 14.008 2.194 0.322 2.362 12.587 9.011 1.005 7.228 7.632 3.232 3.590 5.521 3.494 1.684 6.327 2.909 0.408 2.280 1.135 12.734 0.158 0.996 12.750 8.965 0.965 0.109 6.711 4.175 4.043 13.511 1.543 10.519 4.435 4.968 2.161 4.383 4.091 9.312 9.679 3.878 0.845 4.355 6.994 8.122 5.241 2.472 8.950 10.807 0.202 4.326 7.799 4.746 11.554 0.533 0.445 3.170 8.687 2.897 0.893 0.554 2.551 12.046 0.923 0.101 6.996 6.177 3.884 3.424 3.537 4.378 2.054 2.724 4.805 3.770 3.460 2.457 1.679 10.425 3.120 10.281 7.412 3.623 5.643 1.301 3.645 8.316 0.833 6.312 1.432 3.205 4.870 1.897 9.180 1.488 5.397 3.393 17.401 4.568 3.312 23.317 8.922 3.582 4.032 7.681 1.814 3.934 4.889 6.240 0.863 5.668 1.923 4.302 5.705 10.408 4.591 13.571 9.505 2.396 12.124 0.477 11.927 1.243 5.335 11.642 1.983 5.229 4.554 7.779 2.672 3.243 6.897 2.380 0.922 2.926 9.708 2.426 6.158 8.363 2.119 4.988 0.744 2.499 12.363 5.312 2.825 5.477 3.695 2.895 2.414 0.114 9.942 2.122 1.805 2.600 8.164 1.120 8.187 5.873 3.535 6.330 1.577 5.178 4.924 0.245 0.054 1.687 5.158 11.417 4.703 1.101 6.340 4.893 1.538 10.456 9.107 6.341 1.198 2.370 NA 9.347 NA 9.080 3.637 1.663 2.910 2.036 2.189 4.182 3.398 1.746 5.383 0.105 10.943 6.198 9.068 0.288 8.669 10.420 1.040 0.216 2.447 14.632 1.040 4.391 3.032 4.092 12.806 4.000 7.742 2.279 9.201 2.071 0.858 0.820 2.017 6.542 9.043 3.026 1.233 3.577 15.727 0.621 4.432 4.462 9.967 10.409 2.407 6.146 0.050 2.833 0.274 1.731 0.425 0.257 8.063 3.050 0.675 3.935 1.851 4.614 4.591 1.593 5.197 17.956 2.013 4.790 7.601 2.569 9.223 11.904 5.368 4.018 7.128 4.511 0.994 16.265 4.824 1.718 7.027 2.589 0.536 10.539 0.887 2.801 4.532 6.874 1.539 5.257 16.923 2.702 7.060 3.455 2.017 5.472 0.940 4.606 6.673 3.819 7.061 AZD0530_38_IC_50_uM 966.421 4.825 2.859 10.584 44.759 2.473 120.061 256.262 7.365 13.893 483.427 270.778 16.763 57.231 187.504 6.371 416.714 954.894 3.101 3.052 14.175 9.340 7.701 203.222 7.751 9.503 517.754 3.272 3.855 173.539 100.404 0.608 15.546 369.186 25.870 41.588 51.434 1.683 20.646 2.522 0.534 0.037 9.785 2.025 245.796 1.540 22.644 978.382 616.587 117.495 72.197 3.599 0.206 312.467 99.723 340.257 3.777 440.275 4.207 6.446 5.042 266.560 269.670 1.925 211.347 273.828 98.465 33.458 133.300 21.505 3.309 256.134 8.689 0.710 8.931 5.631 316.683 0.551 1.303 544.626 258.165 1.762 0.350 108.701 27.333 82.533 389.865 1.893 285.574 46.405 42.373 25.389 49.393 51.640 173.330 197.552 33.102 1.702 101.840 231.111 200.858 36.507 145.213 208.659 468.999 0.395 33.351 404.641 35.230 320.794 0.800 0.738 9.832 243.034 82.097 1.364 1.114 7.346 584.876 2.391 0.179 145.300 61.424 38.986 30.223 17.114 13.245 26.547 48.434 150.671 45.746 45.431 4.305 2.989 411.990 9.476 924.728 118.950 16.976 137.291 2.016 94.264 212.406 2.058 187.466 2.853 38.509 57.123 9.909 472.340 2.711 116.385 59.377 677.223 34.213 52.985 11331.027 174.252 15.489 27.647 960.064 5.588 33.576 51.516 135.789 1.267 125.600 33.592 56.081 204.855 241.628 51.259 346.160 215.616 5.182 370.925 1.081 380.886 13.230 142.337 624.968 9.654 160.758 40.270 319.130 5.867 11.436 289.542 14.012 1.646 22.665 348.870 9.930 98.121 259.563 4.376 103.079 2.305 39.213 274.294 74.351 10.725 167.101 28.887 6.654 7.332 0.873 242.112 10.769 3.307 19.666 208.972 4.090 209.432 50.496 26.632 134.129 12.538 53.277 28.968 0.390 0.148 8.521 312.936 460.264 148.013 20.584 181.544 35.220 8.301 334.655 254.525 94.557 1.965 3.465 NA 255.367 NA 218.809 11.316 51.951 8.198 3.233 14.766 11.164 25.572 3.222 80.616 0.964 320.923 190.681 285.146 0.387 744.639 288.069 2.696 7.126 3.901 34392.713 1.504 66.433 8.202 36.889 315.797 30.976 272.817 4.396 230.557 5.388 1.199 1.737 12.725 1302.707 216.957 28.378 2.275 17.855 348.835 1.297 19.340 178.377 312.936 276.884 7.036 136.456 0.132 16.205 0.586 3.862 0.777 0.474 307.754 9.107 1.891 24.710 5.900 76.264 65.261 3.131 318.206 915.710 3.160 143.639 233.481 8.227 266.134 302.506 102.843 28.264 200.778 71.080 1.523 368.817 29.488 8.520 147.614 7.536 16.213 494.427 1.418 9.803 40.903 103.772 2.655 67.377 779.927 43.816 147.835 8.257 2.975 77.316 11.488 261.517 184.860 23.106 662.354 AZD0530_Bayesian_5pctCI_high 188611518.500 25.657 14.480 128.625 8364.066 8.847 2456873.096 76641.961 82.245 1109.983 138870.900 76872.232 352.200 54355.441 2697942.491 78.815 6727404.729 12514518.400 5.287 17.519 2158.351 259.045 56.997 1661447.885 48.274 234.370 53967900.900 13.080 11.463 93442.355 46536.862 2.279 795.444 238780.500 3000.097 3395.818 16559.248 2.926 31875.724 4.210 0.921 0.073 54.310 4.803 3567230.206 18.366 3071.127 21197631.250 19800148.590 92484.838 15624.571 19.543 0.442 105894.649 33179.915 75742.901 17.300 193997.393 14.198 2495.140 24.854 97158.603 284503.263 4.916 599829.064 576251.802 245462.631 6540.049 172421.959 1321.338 10.940 7092156.407 87.427 1.243 203.385 193.040 88362.239 2.354 1.659 21295364.970 124828.990 3.861 1.017 25678.260 2150.165 53492.675 97421.285 2.371 67853.076 9206.822 5328.367 12773.142 12964.887 55370.376 57618.559 42260.157 5655.592 4.462 50397.659 718341.240 85767.892 3883.142 2593710.412 91226.436 6596171.745 0.726 6221.087 19742811.330 4143.930 144798.732 1.176 1.161 122.278 195751.250 43014.821 1.997 2.391 94.076 2659370.504 12.251 0.301 81846.433 11043.530 16745.754 9385.301 569.637 104.983 14960.969 146371.033 90057.173 16532.774 131006.209 16.021 7.873 701025.821 113.863 1747059629.000 44841.979 584.584 104600.122 3.797 533599.054 114130.750 7.493 1056740.787 8.208 20881.106 11840.723 543.049 20499273.410 6.707 143329.292 57647.376 4341801.882 2225.863 24165.953 88264162370.000 53039.914 455.593 2817.485 431854809.200 40.306 8787.627 18764.086 175097.808 1.820 341362.418 39073.509 11174.615 11077205.540 36453.764 12452.790 104099.245 89268.146 26.451 110591.665 2.721 393603.761 2165.702 845260.379 37408181.680 208.554 1589770.144 13468.380 6167474.544 30.314 287.522 6550159.772 769.238 3.514 2844.379 1111254.372 420.313 139343.864 752532.903 18.276 71467.637 13.075 32363.936 62881.042 52928.647 219.423 2485787.329 4445.733 31.757 86.488 15.350 135821.934 344.605 8.608 997.747 443831.382 44.363 262209.741 9058.873 3084.979 148687.193 2452.590 13609.182 1680.086 0.589 0.377 282.902 17137849.560 3849677.744 1649528.422 17697.878 708000.444 2965.497 652.427 374519.818 266412.197 23209.106 3.647 7.104 NA 71446.200 NA 100790.562 136.538 152146.629 94.784 7.062 1890.317 81.941 4831.441 10.358 69940.489 29.459 242364.968 646352.306 703202.373 0.520 392756348.800 472881.449 13.938 10201.602 9.278 249000000000000000.000 2.140 52506.907 81.925 7780.688 78739.483 9228.945 277062.946 20.082 964630.109 29.245 1.660 4.830 804.322 1092134636.000 93657.520 6419.529 6.038 928.992 64543.842 3.496 470.267 3164165.773 365053.793 171888.278 75.929 1428877.887 0.336 1111.872 1.316 20.652 1.480 0.838 7285524.556 88.872 8.926 2246.435 64.078 26702.167 27474.127 12.664 43349251.730 5857889.833 7.330 568183.665 196496.520 124.611 498022.233 152512.220 62317.652 4670.867 1616865.571 23337.108 2.339 115913.558 1418.847 322.144 48898.402 64.438 28575.358 7588921.163 2.258 372.971 3388.356 26149.883 6.819 39183.068 3243293.877 76680.292 38557.272 48.284 5.807 17420.449 4117.494 12058736.790 351196.087 884.215 356056505.700 Rapamycin_Bayesian_5pctCI_low 0.112 0.563 16.124 20.557 5.084 19.969 7.478 32.124 0.182 0.010 43.463 28.078 12.822 8.137 39.338 4.351 0.014 2.454 15.621 0.426 0.265 44.630 7.405 0.851 7.989 3.781 29.154 13.131 0.675 30.542 21.798 2.628 28.709 12.884 21.268 23.829 1.693 0.928 5.382 1.821 1.528 0.001 16.292 16.795 25.315 2.400 3.651 0.013 9.774 14.544 20.450 0.002 6.699 33.298 28.273 51.599 3.139 2.680 16.486 32.694 7.262 0.881 4.429 1.391 1.034 6.635 1.107 0.154 0.005 0.018 5.385 0.055 1.918 4.985 0.004 16.304 0.000 0.005 12.139 40.189 21.778 9.195 3.503 15.484 5.111 67.782 4.942 2.395 44.434 29.815 0.397 4.618 29.277 32.626 0.372 10.761 32.528 52.974 0.025 77.626 17.191 34.932 7.275 10.910 68.088 2.251 0.058 0.038 9.902 1.938 0.003 0.000 44.572 43.350 16.356 0.162 1.603 9.379 0.006 0.309 32.085 32.440 8.431 28.019 0.346 4.354 25.873 8.579 27.495 8.493 24.364 13.327 8.329 50.983 14.052 31.627 32.868 18.686 2.591 1.778 19.018 13.368 6.770 71.080 0.951 12.110 7.471 0.004 10.688 18.047 9.980 21.432 1.266 12.530 5.887 4.399 56.374 40.687 0.216 0.129 0.332 2.555 10.908 8.585 67.034 0.032 32.904 4.022 0.226 40.282 28.380 18.243 5.348 14.041 0.203 12.247 0.000 8.384 3.298 10.892 125.549 16.767 43.772 2.490 40.057 4.561 51.280 78.031 0.023 2.728 4.876 68.020 29.477 0.303 0.118 15.594 5.263 52.615 9.717 87.558 3.529 0.879 3.461 10.070 0.175 1.604 0.671 6.564 10.109 5.085 6.615 39.064 0.000 28.078 3.692 84.902 82.558 0.016 1.319 3.886 1.212 0.855 5.247 25.922 8.942 8.992 12.808 2.787 29.143 12.882 1.308 47.933 37.468 29.265 0.332 1.005 27.913 2.950 10.951 1.113 6.674 13.699 3.734 13.231 56.087 7.772 32.809 71.357 0.421 20.110 21.434 15.640 0.034 0.036 0.495 2.547 46.118 0.161 0.082 12.320 29.248 9.568 2.286 0.479 27.476 2.245 13.519 40.476 3.968 0.232 53.271 4.486 15.342 5.031 11.614 1.558 6.424 79.146 0.735 40.141 11.365 9.540 0.115 0.947 0.925 23.016 0.569 0.074 3.485 0.650 4.086 27.542 0.912 21.012 0.658 1.336 30.637 13.452 24.749 45.191 220.655 16.392 16.211 29.236 33.744 33.805 17.059 1.528 23.905 6.018 23.143 2.000 25.036 23.409 14.546 36.463 0.098 15.038 62.891 13.734 0.983 3.001 1.485 0.067 2.566 18.959 14.207 29.239 2.063 14.187 25.811 0.790 7.053 38.594 0.421 9.040 Rapamycin_3_IC_50_uM 0.393 2.882 282.083 132.781 14.549 709.457 207.431 1154.589 1.181 0.126 673.778 265.204 20.970 14.733 730.625 22.651 0.533 3.503 81.565 4.524 0.576 1218.408 41.108 18.651 17.628 22.851 584.935 280.479 5.992 793.854 1235.585 5.612 2829.909 37.323 222.984 124.362 19.437 12.054 201.926 2.578 3.799 0.016 341.620 2170.038 178.716 35.520 42.056 0.176 34.806 825.591 268.138 0.024 42.756 3152.024 355.633 1174.150 14.093 13.194 1052.686 1049.427 28.474 8.222 19.562 6.665 26.172 693.256 7.400 0.750 0.117 1.059 74.941 0.524 4.694 62.302 0.106 49.417 0.027 0.088 40.451 5133.279 265.257 211.833 25.201 571.863 25.353 82149.826 22.300 4.319 1668.700 784.699 1.946 18.668 785.484 610.696 4.001 137.731 2079.952 14533.331 0.322 1960.196 306.035 1018.718 285.517 93.186 2158.783 20.629 0.385 0.260 43.855 26.862 0.083 0.010 3732.002 1244.016 382.833 0.620 5.050 37.472 0.124 0.721 1445.485 526.894 103.090 1640.572 4.163 6.999 7289.571 245.108 1347.492 178.627 1953.934 605.891 130.139 9214.190 364.636 340.631 7953.760 565.720 4.627 5.923 71.952 123.891 48.994 7204.780 3.939 1312.908 380.924 0.280 487.066 510.250 914.521 1120.018 3.403 266.081 20.479 58.768 1501.020 733.040 1.383 0.390 5.667 240.928 24.670 83.454 4192.699 0.383 5474.192 33.964 1.487 4707.913 445.902 241.870 27.224 222.294 0.715 96.505 0.002 24.908 745.161 119.546 273566.496 461.647 1010.398 20.924 1243.518 31.491 3981.843 105366.497 0.586 11.669 32.114 2098.546 1201.589 4.299 0.842 428.675 71.600 5231.744 246.041 2182.661 23.992 1.929 21.484 98.790 2.005 3.819 23.243 312.093 18.477 78.062 235.662 4772.855 0.00004 357.559 48.492 2419.219 149268.205 0.180 28.749 63.650 24.648 8.344 42.983 1784.333 107.383 206.583 750.170 47.461 217.261 167.268 5.644 6174.604 2849.788 619.368 10.433 32.508 402.140 134.357 50.790 7.840 126.710 58.833 15.322 89.595 11464.379 251.665 4329.035 2222.305 2.686 1649.950 1048.588 81.028 0.228 0.119 1.106 52.678 2303.535 0.496 0.449 76.028 1365.396 251.062 32.082 7.859 570.949 62.878 29.512 627.284 17.516 1.117 31182.116 20.035 107.705 37.018 72.733 15.321 40.817 11847.830 4.383 730.260 171.314 90.505 0.601 6.298 6.947 397.502 1.623 0.913 11.690 3.429 8.778 1083.986 5.057 3353.635 3.398 7.320 695.548 63.829 219.774 1445.774 206963.970 112.990 198.542 437.948 867.573 816.070 718.884 21.795 188.312 171.984 389.008 6.006 1283.056 230.765 109.870 774.486 0.454 648.006 11488.479 44.603 6.288 109.706 3.914 0.631 32.440 432.464 235.427 343.642 24.191 66.407 465.867 12.156 1056.694 1101.579 1.875 299.945 Rapamycin_Bayesian_5pctCI_high 1.173 21.905 308692.218 10339.223 89.497 7572243.888 270763.222 12215302.170 7.782 0.797 353663.084 29231.436 53.335 36.999 481133.472 427.733 11.890 4.982 3587.102 153.439 1.177 1263883.902 952.224 8539.861 80.022 732.820 1146242.776 1071639.203 185.898 19161239.110 51805143.620 14.331 73046004.550 253.687 86275.419 5002.535 1491.891 1178.149 1084901.763 3.715 9.049 0.096 647905.415 932145988.100 26811.871 5467.627 7605.295 1.007 581.668 4009190.867 371164.263 0.127 2046.323 1217298626.000 276094.920 1281190.139 149.351 224.303 14159551.900 2387840.598 639.700 355.882 223.006 76.249 9728.354 37206721.930 179.253 2.938 0.952 80.431 16229.730 4.817 14.822 12268.619 0.882 649.888 1.415 0.527 331.060 1268879418.000 101783.165 81015.842 1303.620 4576293.734 469.374 2150000000000.000 297.585 8.477 9631022.917 3828945.512 12.798 175.037 3204286.492 199246.892 157.323 37861.877 126936814.900 14022093082.000 2.537 625245.718 233257.903 13257844.860 1729944.699 18144.087 3314111.097 1197.031 1.692 1.151 576.976 6683.520 0.611 0.170 1001735668.000 873968.838 1086421.689 2.007 22.156 470.502 0.806 1.565 112021346.000 124866.444 19531.816 302653758.800 151.351 11.617 12608033158.000 476060.392 73478249.850 316918.525 151910182.600 8296132.497 68727.178 3875730507.000 718556.775 65075.278 12816509737.000 3645120.566 8.990 29.105 1592.404 35372.855 2547.837 181288456.000 24.923 109507106.000 4955457.240 9.223 1630993.669 672595.912 32375094.600 59709398.810 10.738 381207.833 396.668 14046.099 638004.107 589128.733 10.916 1.065 556.240 6060482.649 105.299 14181.591 369403462.900 2.941 2522711116.000 3131.602 11.951 2082010812.000 342525.025 45483.277 920.300 207710.383 2.323 7082.626 0.035 271.266 1299311051.000 58735.524 146000000000000.000 529770.938 440162.828 1039.297 849497.265 977.697 101391518.300 6120000000000.000 9.920 113.103 1446.642 1977610.785 21669146.790 208.742 6.012 1378628.883 17111.397 439962476.300 1024484.380 350424.305 774.254 4.525 447.108 14620.793 45.350 10.665 11850.200 2414734.739 65.990 18466.250 453522.427 7309202444.000 0.007 221283.508 6427.237 1201041.914 4190000000000.000 0.917 14436.283 17902.578 10829.184 302.717 2438.650 71721419.590 14956.481 304309.331 12670664.530 14838.790 17373.477 32241.187 44.239 24245575886.000 85557566.520 2832867.479 2222.971 29887.631 418737.705 178599.295 1477.933 178.217 34881.086 1478.377 155.586 1540.096 648000000000.000 644545.051 2928921197.000 865186.180 21.695 245301837.500 20932216.720 3284.271 0.904 0.324 1.950 34634.307 50967564.590 1.317 1.820 2297.094 33817872.740 490803.930 7952.964 941.242 695092.355 66542.758 159.381 146297.866 224.798 5.241 8160000000000.000 241.387 3451.969 1463.228 8771.824 794.967 1550.604 1334203071.000 45.327 650502.227 249446.564 25301.020 2.798 111.665 265.151 422776.944 4.728 10.222 85.601 30.588 26.288 2805240.968 64.264 1204463408.000 31.563 103.121 226545.254 4379.982 48165.583 1155911.768 119000000000.000 5559.147 31659.705 197738.356 1057480.764 1208028.198 18281496.750 2767.501 21373.348 403527.533 542802.059 26.805 7390456.029 74176.302 24740.578 1074858.948 1.624 8454420.511 5349131242.000 763.414 90.098 365455.573 12.896 5.082 3736.483 976763.662 414571.195 78291.945 2826.516 1194.401 685703.090 1137.172 230140373.400 693148.818 12.069 517621.728 Sunitinib_Bayesian_5pctCI_low 3.566 6.884 5.206 23.081 2.267 7.971 6.150 4.779 10.452 0.002 60.340 16.412 16.397 8.672 17.896 5.298 11.819 12.406 5.203 3.269 12.014 12.599 3.257 17.893 5.054 9.369 6.506 12.432 16.971 15.007 11.414 8.813 18.399 35.368 10.666 6.801 4.692 4.284 11.995 10.187 4.859 0.309 13.621 6.973 18.216 1.489 14.395 79.020 31.734 36.503 7.884 2.667 5.028 18.923 17.453 68.896 12.576 6.301 3.193 20.561 8.811 4.104 4.090 7.610 5.470 4.878 15.911 11.007 1.756 7.888 19.660 2.797 17.720 3.829 4.526 33.092 28.657 7.767 11.907 42.470 15.855 9.767 9.150 8.462 13.006 29.836 10.541 6.457 8.188 11.837 3.727 7.875 13.626 17.094 79.854 5.643 7.186 11.619 11.745 20.641 2.913 21.120 59.776 23.357 25.829 1.544 11.101 0.839 14.426 16.007 2.255 3.231 32.518 2.023 10.952 5.989 3.498 8.718 10.122 8.637 3.411 24.064 15.814 13.796 2.082 8.753 9.905 4.794 14.589 32.505 22.202 0.623 4.373 3.867 4.368 16.218 10.413 8.114 1.264 0.789 6.978 27.151 7.352 41.621 8.434 6.185 17.162 5.764 9.193 12.555 4.078 17.291 7.027 7.735 3.319 12.293 60.764 14.358 5.876 1.253 22.753 4.277 2.284 12.989 37.506 34.595 6.129 33.115 14.271 19.545 11.571 10.429 7.053 10.988 5.927 17.715 2.093 2.823 7.776 3.057 7.445 13.568 20.918 8.238 30.652 23.255 8.578 22.665 7.620 3.282 5.284 13.314 6.221 7.340 37.270 3.999 9.919 11.379 8.033 61.738 3.699 0.038 8.087 5.710 6.833 2.233 24.223 10.964 27.429 7.854 36.620 36.617 1.161 5.119 4.651 15.061 53.968 2.653 3.279 11.282 4.849 1.990 6.550 10.847 6.433 25.513 7.610 2.993 16.221 5.936 7.950 30.720 4.743 17.328 3.108 1.188 3.593 10.835 8.258 5.266 3.585 8.613 5.756 13.903 10.018 51.229 6.648 64.806 2.411 13.247 6.137 18.019 2.785 13.417 6.920 14.954 29.169 4.974 6.857 6.283 7.946 7.357 2.120 1.301 9.961 8.254 13.257 16.893 13.666 4.562 5.211 10.423 9.229 7.939 5.832 1.897 5.413 10.334 1.574 21.464 5.393 6.084 18.526 5.067 4.430 9.101 2.033 2.888 17.099 1.454 12.293 11.410 2.497 6.115 17.350 11.071 25.399 17.837 33.582 43.855 12.275 6.975 13.549 20.092 5.078 12.582 8.785 3.465 13.143 6.759 19.296 5.485 11.491 8.979 12.467 33.535 3.483 39.154 7.272 12.770 4.082 7.723 4.170 2.649 4.105 7.592 37.476 14.969 6.078 6.778 4.568 5.012 31.642 15.293 4.033 21.652 Sunitinib_5_IC50_uM 5.721 14.326 10.625 177.701 3.489 20.247 9.154 7.291 17.063 0.030 1610.178 75.899 36.543 14.273 100.766 9.834 36.606 19.206 9.137 6.360 25.209 43.864 5.088 57.835 8.059 21.115 8.918 46.090 49.735 45.504 92.010 11.263 73.810 442.526 15.649 10.237 8.171 7.808 99.863 16.045 7.369 0.523 39.468 26.680 60.491 3.310 165.273 2561.120 848.695 962.563 17.250 3.682 6.881 189.730 70.626 1842.724 29.403 10.450 4.378 240.567 20.118 7.090 7.289 11.326 10.426 7.761 74.321 19.961 6.381 15.978 476.230 5.811 80.729 6.259 7.174 347.756 581.668 12.320 23.836 671.021 77.215 16.135 15.043 18.196 36.580 545.771 18.181 8.081 11.323 27.023 5.774 9.470 51.568 160.100 225280.146 9.397 10.815 45.060 74.791 133.780 5.028 218.809 1524.924 235.804 597.587 2.536 29.297 1.580 29.224 393.350 3.464 4.709 483.911 4.072 47.651 8.520 5.318 14.924 15.737 21.995 5.125 272.626 46.330 60.093 5.363 14.874 22.249 7.419 51.754 840.419 1623.436 1.534 12.060 5.392 6.473 34.560 24.938 14.478 1.822 1.501 10.092 570.721 10.736 1006.365 12.931 9.754 111.653 11.852 16.226 24.257 8.822 250.210 9.112 12.711 6.453 145.314 1289.745 31.836 7.344 1.818 301.841 14.635 3.111 43.742 1160.609 795.444 14.276 736.272 36.104 91.946 21.377 14.038 14.417 63.982 9.287 97.749 3.655 5.411 231.644 5.191 10.444 270.941 203.365 43.659 628.792 93.738 23.670 239.128 10.024 6.399 10.776 26.666 12.759 37.185 1267.625 7.199 18.386 20.092 71.165 1150.785 5.853 0.139 10.079 13.594 12.450 3.120 609.172 16.436 266.800 10.818 3658.469 1576.717 1.914 7.118 8.812 25.979 1437.269 4.413 5.460 24.508 6.331 3.733 8.014 21.272 11.828 261.910 22.540 10.926 54.888 8.269 19.206 425.941 6.576 65.871 9.609 3.245 5.104 268.755 18.060 9.684 6.249 14.027 8.151 20.739 14.948 1242.897 10.295 4484.131 4.052 141.783 10.122 147.275 4.145 22.840 10.167 96.583 1157.017 6.259 8.892 8.202 20.797 17.236 7.968 2.591 24.560 24.325 26.837 45.409 39.769 7.209 7.802 16.653 12.162 17.203 17.681 2.972 15.632 13.476 2.365 133.033 12.075 16.117 101.799 10.166 6.882 27.860 3.199 4.170 125.939 2.313 50.325 19.525 4.039 9.150 51.162 34.257 582.891 118.073 593.893 1070.949 24.633 9.864 46.381 72.147 7.416 36.723 21.253 6.236 30.732 16.942 208.346 9.426 19.615 15.632 38.256 521.808 4.792 1146.879 10.939 31.976 6.079 59.365 5.539 4.368 6.521 13.314 1062.628 36.911 26.154 8.665 6.705 14.348 635.429 230.350 6.411 317.285 Sunitinib_Bayesian_5pctCI_high 9.240 53.239 32.453 29551.802 5.233 167.101 15.621 11.304 49.146 0.151 421131.325 4212.873 210.103 29.621 10878.025 23.646 572.779 46.815 18.326 13.079 124.400 894.442 7.736 1140.019 13.507 150.460 12.251 1228.071 469.562 588.278 15967.329 16.309 1831.334 69598.619 32.362 16.949 17.041 15.686 20118.599 36.514 10.933 0.850 572.321 574.442 1031.119 7.261 44609.405 1710335.315 520320.372 3633474.823 70.372 4.982 9.088 48397.334 1670.870 1471510.526 149.366 20.683 5.826 105566.884 85.285 12.575 13.959 19.404 29.500 12.929 2963.422 69.860 38.671 82.319 1291480.768 13.193 3921.776 9.955 11.509 71367.653 185702.275 26.531 96.786 132203.807 4705.560 33.208 37.604 65.229 446.438 628694.044 52.326 9.909 17.364 167.888 8.789 11.695 1279.468 32620.624 32800000000000.000 17.717 20.861 575.593 9455.010 9909.013 7.956 36008.129 413784.258 94032.900 3581169.568 4.253 334.956 2.954 111.687 302852.147 5.130 6.561 231908.923 8.156 2170.255 12.860 7.684 40.346 34.834 115.077 7.218 41630.985 562.392 1869.264 16.010 41.380 130.035 11.595 1158.985 267694.049 27172065.500 3.428 87.392 7.010 9.128 137.030 205.121 39.650 2.644 2.848 16.507 185183.036 18.178 2893276.052 24.102 18.737 10997.244 40.411 48.323 81.037 24.117 194482.993 12.284 28.606 13.918 64893.322 461759.744 179.684 8.964 2.657 77450.941 134.693 4.263 899.645 6074437.802 1250307.401 64.348 322352.195 312.467 3636.947 71.672 24.690 53.213 6209.279 15.580 6854.770 6.039 9.863 1579154.287 8.680 15.847 174817.876 95301.421 3967.137 238876.032 2147.372 181.544 96220.720 13.773 13.821 29.687 120.422 38.955 2668.042 5681353.190 13.913 56.974 56.368 11785.203 159149.613 9.245 0.369 13.314 56.509 28.890 4.388 200766.938 33.727 41357.125 17.567 797266851.000 47180913.790 3.117 9.600 20.108 62.771 1164147.945 7.307 9.215 195.469 8.002 6.950 9.569 100.053 28.451 63240.488 163.514 76.746 1761.815 11.395 134.801 89187.841 8.528 1367.446 58.962 8.065 6.853 205890.551 76.432 25.495 11.423 32.408 11.588 42.203 30.889 452435.278 19.188 396902017.100 6.366 63481.259 22.984 23162.735 5.975 62.903 16.195 10657.296 25138221.130 7.676 11.686 10.468 136.088 84.369 63.055 5.185 153.930 352.095 109.410 384.906 404.681 12.230 11.578 40.683 18.212 69.338 106.102 4.453 113.443 20.473 3.526 10478.701 53.780 149.590 5037.172 26.902 10.193 355.811 4.888 5.872 17371.740 3.562 2002.597 61.350 6.033 16.350 562.505 277.605 365345.953 19643.465 184776.081 277395.621 80.681 15.976 611.124 1320.281 10.658 512.961 156.773 11.501 238.698 93.522 36588.893 19.822 56.770 44.155 544.354 146561.439 6.357 336112.095 20.316 315.135 9.079 11693.636 7.124 6.748 9.670 34.970 514525.296 256.313 792.189 10.943 9.253 85.328 1040279.516 179979.818 9.809 256812.108 PHA665752_Bayesian_5pctCI_low 2.927 4.877 3.485 3.413 3.694 3.275 4.158 3.070 2.084 1.593 8.003 5.611 8.837 4.797 5.248 151.608 2.692 4.884 1.963 1.693 0.779 4.621 2.436 2.742 3.861 4.227 5.707 3.474 6.161 7.903 3.048 7.191 4.894 6.759 7.256 3.128 6.611 2.148 3.682 4.008 7.146 0.432 6.863 3.719 7.629 3.043 3.866 4.147 7.392 4.656 5.685 4.419 8.602 8.120 4.327 7.399 4.866 3.085 7.236 5.092 7.313 1.931 1.554 7.240 2.031 5.661 4.777 4.065 20.710 4.379 0.590 1.090 6.557 5.035 1.429 7.297 5.029 0.812 5.255 4.884 4.793 1.442 1.843 4.216 4.506 6.598 2.971 7.444 5.369 5.988 1.227 4.502 4.665 6.347 6.582 1.126 2.508 3.283 4.337 8.135 2.798 3.165 3.839 6.582 6.087 3.565 1.643 2.438 5.243 0.837 1.761 6.374 3.928 1.048 4.603 6.262 3.913 5.616 3.532 1.619 7.738 5.161 2.729 4.359 1.904 6.767 2.576 3.374 6.563 5.669 2.957 3.041 3.623 3.881 3.876 6.076 5.915 2.881 5.559 2.878 2.871 2.415 3.533 7.940 2.270 1.894 1.830 1.691 1.885 2.002 6.595 5.400 6.034 6.748 2.068 0.945 5.155 4.060 2.760 0.210 3.723 3.535 4.544 5.504 6.381 5.672 2.333 5.174 3.508 7.219 7.813 2.166 2.131 2.572 1.370 7.074 0.630 2.281 2.922 7.246 4.649 1.939 5.952 0.000 3.508 8.898 1.189 5.278 4.479 1.549 4.391 7.448 4.778 6.251 4.130 3.642 3.436 5.422 2.460 8.105 2.538 91.031 6.082 2.341 2.157 2.392 0.501 9.005 7.472 4.396 2.049 2.858 0.918 8.121 2.414 7.174 6.188 3.991 1.646 1.826 1.951 0.668 5.188 2.576 86.522 4.924 3.744 3.235 2.455 6.082 2.257 3.093 4.162 3.902 1.403 1.523 7.275 0.042 2.322 1.887 3.079 4.291 2.824 1.756 0.343 5.374 4.283 5.549 5.658 4.532 5.482 6.334 2.663 1.748 1.969 1.515 5.857 1.885 1.873 3.093 3.606 5.500 1.311 0.674 6.805 3.340 8.349 4.789 3.353 2.969 4.952 3.456 5.642 2.339 4.539 5.183 2.073 10.445 1.587 6.012 3.874 4.404 3.553 3.142 4.312 5.729 4.389 2.624 2.250 3.078 1.545 7.223 2.519 3.865 2.311 2.905 3.897 4.348 5.654 6.059 2.675 2.111 3.390 7.026 5.241 4.427 5.241 1.255 3.439 2.355 2.367 4.221 3.054 4.393 2.812 4.720 2.099 2.890 4.642 4.605 2.785 0.769 8.405 1.494 5.284 6.133 4.282 4.182 1.566 3.197 3.504 2.854 2.535 4.933 0.856 3.844 PHA665752_6_IC_50_uM 36.328 140.471 80.278 48.216 66.887 100.103 102.207 46.224 10.780 11.491 208.450 167.386 329.113 317.888 223.252 111479.946 42.747 92.555 8.900 3.081 1.266 132.661 20.679 28.703 66.029 96.322 151.745 85.858 142.965 222.427 101.028 211.072 133.393 196.783 262.723 33.278 213.172 35.294 102.125 73.237 199.537 0.638 198.621 110.013 248.241 86.921 124.674 77.107 284.491 82.872 156.397 128.741 258.191 238.078 96.795 311.750 210.545 46.605 1710.601 171.503 220.412 2.979 7.485 226.490 20.761 223.587 117.413 90.080 4410.309 117.648 1.473 36.158 330.895 104.282 5.209 290.006 141.925 3.155 138.393 144.836 96.583 3.080 10.014 114.343 120.892 207.286 39.209 208.263 163.531 149.575 3.509 639.509 117.378 152.643 255.443 3.226 29.684 138.657 168.141 241.459 103.939 51.060 90.170 211.579 163.809 83.154 15.524 34.719 230.442 15.255 8.618 506.285 70.782 5.462 132.914 183.571 87.488 163.694 67.667 4.972 231.783 139.268 29.583 132.026 20.285 166.717 28.449 70.732 184.786 155.602 90.315 118.605 125.625 66.900 174.758 114.617 170.034 47.465 261.021 67.694 31.287 43.847 51.785 177.932 3.239 2.738 2.773 2.540 2.735 2.757 2182.661 138.338 154.609 178.591 41.571 10.360 99.903 60.558 21.486 0.297 98.288 1315.800 261.569 193.040 208.304 2209.011 91.845 138.518 96.563 258.062 224.842 8.266 25.798 62.602 4.147 191.943 1.117 34.213 418.468 226.218 67.620 4.016 160.036 0.008 88.943 251.263 3.181 600.162 100.143 10.500 177.133 243.204 205.265 212.916 122.229 91.304 60.667 100.746 94.434 227.238 75.001 24964.248 100.394 36.046 3.143 16.720 6.373 463.543 176.267 69.526 37.341 119.953 1.224 242.330 3.941 319.961 172.259 117.319 2.531 9.030 6.310 1.237 90.206 4.074 30933.654 182.381 86.817 144.763 16.379 149.770 34.134 47.177 90.786 112.460 3.107 3.024 146.731 0.273 27.558 2.950 69.728 105.541 22.815 3.557 1.139 351.672 110.233 295.273 161.790 107.501 148.235 179.846 18.421 3.986 7.373 8.370 283.043 5.328 6.749 27.010 98.229 135.030 21.075 2.734 198.205 85.021 244.863 84.150 63.656 25.138 121.243 49.610 135.233 25.920 651.189 218.438 26.143 288.934 4.364 2302.153 96.197 118.179 79.663 91.579 100.695 143.266 102.976 32.278 28.045 66.294 9.875 188.350 44.376 82.352 10.497 50.285 86.005 107.716 126.040 193.234 12.431 12.320 65.451 148.309 120.784 109.104 141.514 4.230 59.758 4.069 54.604 171.229 27.780 98.307 47.565 117.472 8.212 77.812 138.990 120.325 61.075 3.065 258.088 6.000 149.112 178.877 120.518 93.335 17.530 29.119 66.500 113.886 44.071 164.844 1.537 462.478 PHA665752_Bayesian_5pctCI_high 17252.287 84372.770 18631.333 20390.003 20685.743 73784.208 45935.798 14581.371 509.179 1501.470 74548.112 791511.747 213160.355 196800286.800 6069580.195 876000000000.000 95616.435 43174.270 231.320 5.140 2.815 51549.614 4712.152 5059.890 14209.983 39454.366 59018.132 47652.959 34926.460 77396.745 262866.085 106884.063 178777.984 365053.793 259263.449 6512.639 141322.529 22205.605 84931.472 65597.968 79062.978 0.920 131439.244 290628.181 312950.403 110271.413 110117.141 37380.333 218119.858 16993.735 49513.468 338540.835 97139.173 126943.832 42997.618 5473342.237 14415289.900 24834.771 3359305187.000 256889.163 105240.133 4.564 273.609 92957.716 3478.652 397559.545 63959.158 73732.577 9446404218.000 87273.313 7.235 139093.271 6488227.896 25727.095 94.113 1441651.659 82925.675 46.885 36938.144 113051.642 23167.368 13.483 658.458 148464.329 60687.923 154708.813 8894.603 252180.404 376660.677 50700.954 25.713 181524284.200 72301.489 33060.682 1941361.327 27.369 13676.031 1772674.534 524761.945 165727.475 1864493.514 9028.125 25427.842 155065.052 81275.508 40207.145 9706.005 25871.571 9396990.158 4959.697 334.153 59091638.980 46018.557 183.021 37571.460 146005.563 25124.532 216057.531 71625.039 68.800 69975.468 62174.486 12491.454 228547.650 9981.613 45802.777 13489.947 151873.012 87203.522 66449.663 471700.722 3239404.258 33654.431 23887.247 4959423.192 12256.357 91949.979 15559.085 4248599.682 65827.963 5204.089 24411.265 12162.345 29439.718 4.517 3.959 4.127 3.922 4.012 3.861 1090715784.000 33543.554 320295.729 62617.496 16244.343 5053.822 71196.576 16980.145 4528.744 0.420 52391.519 11226018484.000 67957971.100 233304.559 109556.974 128000000000.000 473780.778 48523.330 408766.759 136311.774 57884.215 146.028 11353.712 82355.457 55.534 63297.430 2.787 13124.028 1327548705.000 76949.143 23915.929 7.752 75886.949 0.061 35660.539 78276.288 20.412 567300668.100 55017.137 1610.983 1644093.950 192201.581 3435936.221 181734.117 47676.791 209755.952 54008.677 17142.225 1171505.228 60421.483 751630.405 10010496205.000 11639.968 19625.794 4.581 1932.945 1973.374 8930652.335 45387.862 17399.557 47557.748 3751251.216 1.591 129262.435 6.061 14915328.490 59706.729 517414.721 3.847 338.424 91.113 3.809 65558.621 6.136 48547085549.000 1091976.593 65538.956 1514657.653 1121.811 47987.700 7443.526 40352.152 95063.465 571660.178 6.332 5.333 23949.435 3.768 12997.340 4.529 213437.643 187343.667 1754.256 12.131 6.255 83245114.470 35013.886 30410545.570 70883.999 31172.763 54301.113 55703.597 1569.010 19.682 130.451 688.214 2794321.835 41.604 99.176 6928.510 76910.678 45147.943 9050.724 49.131 59379.243 75644.499 142400.672 42062.000 26055.913 5498.882 48484.527 7594.655 48469.984 8785.870 3978218727.000 1467689.568 10934.738 110447.989 32.259 32412176272.000 44174.368 53503.374 51776.932 140098.356 26006.454 54934.673 56078.064 26053.307 8346.520 81487.100 631.628 58290.826 23304.459 53503.374 211.833 19680.823 27029.929 44515.824 25634.644 70798.989 294.565 718.596 153767.961 19040.051 26048.097 34210.914 60803.340 73.781 41117.948 6.422 131399.818 2068429.124 2770.270 20729.229 20286.278 55887.722 172.001 53247.173 249222.163 78049.616 84019.148 63.149 87772.191 156.523 111312.852 96945.089 72787.535 118503.764 8705.410 3410.793 52981.602 2282541.333 39687.835 121540.157 4.418 1068583739.000 MG-132_Bayesian_5pctCI_low 0.045 0.394 0.182 0.372 0.276 0.276 0.270 0.384 0.035 0.096 0.699 0.328 0.353 0.896 0.302 0.230 0.096 0.040 0.295 0.106 0.295 0.188 0.274 2.466 0.027 0.180 0.254 0.052 0.214 0.362 0.175 0.164 0.210 0.273 0.274 0.766 0.106 0.352 4.921 0.019 0.079 0.020 0.344 0.537 0.375 0.195 0.184 0.064 0.186 1.869 0.319 0.027 0.052 0.204 1.012 0.463 0.139 0.248 1.007 0.683 0.515 0.205 0.149 0.020 0.407 0.023 0.265 0.019 0.466 0.142 0.021 0.093 0.568 0.139 0.119 0.878 0.162 0.103 0.036 2.192 0.416 0.391 0.031 0.304 0.029 0.282 0.787 0.154 0.024 0.450 0.161 0.298 0.547 0.175 6.560 0.215 0.149 0.124 0.156 0.667 0.162 1.207 0.121 0.038 0.237 0.171 0.008 0.260 0.239 0.069 0.068 0.236 0.600 0.147 0.253 0.030 0.154 0.189 0.039 0.029 0.136 0.471 0.226 0.173 0.253 0.076 0.603 0.023 0.176 0.128 3.737 0.006 0.161 0.232 0.247 0.928 0.328 0.223 0.134 0.190 0.092 0.180 0.081 0.420 0.142 0.190 0.159 0.169 0.149 0.184 0.127 0.037 0.170 0.133 0.168 0.253 3.262 0.354 0.434 0.239 0.185 0.027 0.018 0.253 0.411 0.033 0.011 0.316 0.228 0.180 0.256 0.202 0.240 0.306 0.026 0.226 0.162 0.018 0.003 0.198 0.394 0.039 2.522 0.120 0.296 0.194 0.329 1.645 0.166 0.272 0.026 0.467 0.075 0.144 0.116 2.172 0.278 0.092 0.004 0.311 0.217 0.099 0.526 2.972 0.558 0.275 0.161 0.382 0.137 0.337 0.719 0.571 0.116 0.621 0.385 0.558 1.185 0.100 0.299 0.285 0.121 0.112 0.256 0.258 0.215 0.486 0.304 0.138 1.036 0.177 0.145 0.305 0.693 0.130 0.041 0.154 0.170 0.017 0.272 0.145 0.160 0.235 0.469 0.327 0.305 0.015 0.475 10.428 0.119 0.023 0.164 0.266 0.231 0.217 0.026 0.141 0.349 0.161 0.544 0.350 0.251 0.163 0.160 0.137 0.279 0.252 0.137 0.363 0.342 0.124 0.205 0.729 0.377 0.384 1.018 0.147 0.217 0.172 0.324 0.107 0.071 1.529 0.417 0.444 0.028 0.186 0.400 0.456 0.207 0.214 0.026 0.227 0.126 0.166 0.265 0.290 0.706 0.481 0.429 0.106 0.958 0.165 0.366 0.303 0.232 0.188 0.144 0.212 0.737 0.070 0.232 0.144 0.288 0.210 0.155 0.818 0.199 0.080 0.232 0.325 0.281 0.133 0.047 0.213 0.322 0.223 0.368 0.283 0.155 0.220 0.303 0.585 0.156 0.121 0.268 0.524 MG-132_9_IC_50_uM 0.066 0.582 0.316 0.528 0.402 0.512 0.413 0.545 0.048 0.159 0.912 0.447 0.467 1.172 0.458 0.874 0.141 0.053 0.423 0.191 0.442 1.550 0.394 14.311 0.040 0.281 0.362 0.084 0.300 0.518 0.412 0.209 0.303 0.398 0.388 1.017 0.235 0.545 164.910 0.026 0.104 0.029 0.855 1.334 0.512 0.313 0.896 0.086 0.383 18.737 0.495 0.038 0.091 0.392 1.750 0.657 0.228 0.371 1.794 1.318 0.622 0.317 0.227 0.028 0.610 0.059 0.445 0.025 0.709 0.217 0.034 0.174 0.752 0.193 0.175 1.160 0.260 0.154 0.050 51.811 0.679 0.526 0.046 0.470 0.042 0.458 1.120 0.188 0.035 0.637 0.229 0.409 0.837 0.629 132.954 0.319 0.216 0.267 0.298 0.875 0.250 3.653 0.321 0.056 0.377 0.265 0.012 0.365 0.323 0.205 0.096 0.339 0.793 0.228 0.505 0.043 0.218 0.272 0.053 0.042 0.191 0.755 0.322 0.272 0.408 0.135 2.072 0.033 0.260 0.255 69.770 0.022 0.299 0.324 0.349 1.233 0.641 0.344 0.191 0.299 0.111 0.310 0.130 0.557 0.176 0.276 0.227 0.214 0.200 0.227 0.187 0.102 0.248 0.218 0.306 0.583 45.943 0.489 0.575 0.368 0.288 0.081 0.028 0.431 0.648 0.051 0.039 0.638 0.317 1.386 0.364 0.268 0.368 0.626 0.037 0.335 0.258 0.033 0.014 0.325 0.643 0.192 33.435 0.233 0.511 0.257 0.436 5.618 0.219 0.440 0.041 0.664 0.126 0.206 0.267 20.635 0.408 0.131 0.014 0.425 0.356 0.122 0.737 54.293 0.847 0.400 0.327 0.494 0.189 0.546 8.000 0.789 0.183 0.858 0.599 0.709 1.674 0.150 0.475 0.400 0.176 0.175 0.381 0.539 0.455 0.687 0.487 0.272 1.653 0.249 0.280 0.496 0.991 0.262 0.080 0.272 0.244 0.129 0.418 0.195 0.242 0.366 0.682 0.451 0.405 0.026 0.736 336.972 0.187 0.184 0.265 0.374 0.360 0.297 0.037 0.249 0.596 0.208 0.672 0.466 0.539 0.235 0.336 0.241 0.432 0.438 0.182 0.489 0.490 0.161 0.305 1.171 0.514 0.529 1.541 0.230 0.374 0.229 0.475 0.151 0.129 16.964 0.602 0.800 0.042 0.291 0.572 0.653 0.333 0.299 0.041 0.324 0.196 0.242 0.379 0.403 2.124 0.749 0.613 0.250 1.385 0.231 0.506 0.428 0.333 0.336 0.217 0.341 1.414 0.127 0.438 0.207 0.416 0.314 0.301 2.009 0.259 0.170 0.357 0.498 0.412 0.229 0.060 0.321 0.490 0.328 1.865 0.399 0.374 0.298 0.431 1.026 0.243 0.316 0.398 0.831 MG-132_Bayesian_5pctCI_high 0.097 0.787 0.533 0.694 0.560 0.932 0.607 0.718 0.065 0.267 1.192 0.601 0.591 1.716 0.658 6.865 0.206 0.069 0.573 0.335 0.638 80.254 0.551 721.765 0.058 0.435 0.501 0.131 0.426 0.689 0.927 0.274 0.447 0.562 0.530 1.456 0.491 0.776 138441.066 0.038 0.132 0.045 3.402 6.816 0.648 0.480 11.239 0.115 0.719 4937.429 0.703 0.053 0.165 0.715 4.321 0.851 0.363 0.540 5.292 4.374 0.734 0.485 0.351 0.039 0.860 0.137 0.677 0.034 1.070 0.344 0.052 0.318 0.968 0.284 0.253 1.753 0.422 0.232 0.065 1564379.785 1.103 0.685 0.065 0.685 0.058 0.690 1.836 0.239 0.049 0.854 0.343 0.549 1.399 3.234 23223.036 0.465 0.323 0.520 0.535 1.117 0.393 54.413 0.838 0.079 0.560 0.404 0.017 0.501 0.452 0.569 0.130 0.485 1.004 0.360 0.970 0.059 0.318 0.400 0.069 0.060 0.285 1.227 0.455 0.420 0.622 0.259 35.945 0.047 0.389 0.472 23281.166 0.062 0.494 0.461 0.488 1.926 1.347 0.512 0.278 0.451 0.134 0.505 0.221 0.725 0.225 0.403 0.347 0.281 0.280 0.282 0.271 0.266 0.370 0.363 0.548 1.646 17051.612 0.646 0.725 0.552 0.443 0.201 0.043 0.684 0.963 0.076 0.127 1.466 0.447 57.008 0.513 0.368 0.531 1.282 0.053 0.486 0.404 0.057 0.042 0.509 1.056 0.528 13856.365 0.424 0.824 0.357 0.569 99.097 0.298 0.653 0.059 0.904 0.195 0.311 0.570 2933.642 0.582 0.186 0.038 0.565 0.572 0.152 1.001 14502.843 1.277 0.563 0.610 0.622 0.261 0.865 5171.407 1.080 0.279 1.215 0.863 0.892 3.049 0.229 0.704 0.547 0.251 0.280 0.557 1.133 0.980 0.900 0.726 0.464 4.390 0.356 0.494 0.742 1.552 0.523 0.142 0.446 0.358 0.751 0.612 0.264 0.371 0.540 0.938 0.603 0.528 0.044 1.146 153660.361 0.302 1.383 0.420 0.527 0.527 0.404 0.051 0.434 0.935 0.279 0.791 0.602 1.229 0.350 0.656 0.441 0.631 0.683 0.252 0.642 0.655 0.211 0.456 2.567 0.675 0.688 3.487 0.367 0.606 0.315 0.658 0.209 0.225 5120.974 0.836 1.656 0.062 0.454 0.782 0.902 0.512 0.424 0.062 0.461 0.324 0.370 0.529 0.560 27.938 1.173 0.831 0.519 2.540 0.331 0.661 0.583 0.470 0.562 0.349 0.529 4.315 0.214 0.735 0.315 0.579 0.466 0.515 16.555 0.350 0.347 0.524 0.703 0.570 0.393 0.075 0.480 0.702 0.471 45.020 0.541 0.860 0.412 0.592 2.450 0.383 0.699 0.573 1.379