Department of Computer Science and Engineering
University of Washington

Shape-Based Retrieval of 3D Craniofacial Data

The Ontology of Craniofacial Development and Malformation

This research is supported by the National Institute of Dental and Craniofacial Research under Grant No. 1U01DE020050-01.

Project Summary:

Craniofacial abnormalities comprise over half of all congenital malformations, and are often associated with complex syndromes with considerable phenotypic variability. NIDCR sponsored the creation of FaceBase, a consortium of 8 biology projects, 2 technology projects, and a data coordinating Hub, the purpose of which is to systemically acquire and integrate multiple forms of data in order to facilitate a systems level understanding of the causes and possible treatments for craniofacial abnormalities. An overview of the FaceBase projects has been published in Developmental Biology.

The FaceBase Consortium needs standardized terminologies to describe the quantitatively defined phenotypes, so they may be related to non-quantitative information. The goals of this new subproject are to develop an Ontology of Craniofacial Development and Malformation (OCDM), and to demonstrate its usefulness for both the parent project and the FaceBase consortium as a whole. The primary demonstrations will be: 1) precise phenotype annotation through consistent naming and quantification, and 2) integration of multiple sources of data.

People:

Linda Shapiro, PI
James Brinkley, Key Personnel
Michael Cunningham, Key Personnel
Carrie Heike, Key Personnel
 Timothy Cox, Key Personnel
Brinkley
Harry Hochheiser, Key Personnel
 Onard Mejino, Senior Scientist
 Todd Detwiler, Research Scientist
Ravensara Travillian, Postdoctoral Fellow





Publications